Mupirocin
Mupirocin is antibiotic, previously known as pseudomonic acid.Used as an ointment to treat bacterial skin infections. Mupirocin is active against gram positive bacteria. Mupirocin is rapidly inactivated following oral administration the absorption and systemic levels are undetectable. Mupirocin is used topically. Mupirocin is also used for elimination of certain nasal bacteria as part of an infection control program.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Pseudomonic Acid.
It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action. It is also classified under Dermatological Products .
Molecular Weight: 500.6 · pKa: 5 · Solubility in Water: Slightly soluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Mupirocin.
Pharmacokinetics
Distribution: Mupirocin has a plasma protein binding is 95%.
Elimination: renal excretion is Urine.
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Indications
Mupirocin is primarily indicated in conditions like Eczema, Folliculitis, Furunculosis, Impetigo, Nasal infection, Skin infections.
Contraindications
Mupirocin is contraindicated in conditions like Wounds, Burns, Hypersensitivity.
Dosage
Mupirocin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2 % | 2 % | Every 8h | Topical | Upto 10 days |
| Paediatric Dosage (20kg) | ||||
| 2 % | 2 % | Every 8h | Topical | - |
| Neonatal Dosage (3kg) | ||||
| 2 % | 2 % | Every 8h | Topical | - |
Drug Interactions
None recorded.
Side Effects
Mupirocin is known to cause more or less tolerable side effects which are usually transient. These include Burning sensation, Cough , Cutaneous reaction, Dysgeusia, Headache, Itching, Local pain, Nasal irritation, Pharyngitis, Pruritus , Rashes , Rhinitis , Stinging on application, Systemic allergic reactions.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.13.2.1 — Antibacterials, topical