Mianserin

Drug #483

Mianserin was introduced in 1976 as an antidepressant, Mianserin has a novel tetracyclic structure and a pharmacological action that differed from previuos antidepressant drugs. itused to treat depression, nerve pain, insomnia, bed-wetting in children older than six years.

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Primary Characteristics

It belongs to Amines.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Tetracycylic Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 300.8 · pK_a: 7.05 · Solubility in Water: Springaly soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Mianserin.

Pharmacokinetics

Absorption: Mianserin has an oral bioavailability is 80% (±10%), pre-systemic (first-pass) metabolism accounts for 70%.

Distribution: Mianserin has a volume of distribution is 13 l/kg. plasma protein binding is 96.4 %.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 6-40 hr, renal excretion is 70 %.

Indications

Mianserin is primarily indicated in conditions like Anxiety, Depression.

Contraindications

Mianserin is contraindicated in conditions like Mania.

Dosage

Mianserin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
60 mg	60 mg	Every 24h	PO	Initial dose 30 mg
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mianserin in overdosage may give rise to further complications which include Hepatic damage , Jaundice , Jaundice , Breast cancer , Polyartheopathy.

Mianserin produces potentially life-threatening effects which include Agranulocytosis, Blood dyscrasias, Anxiety, Aplastic Anemia , Aplastic anemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Mianserin are Death .

Mianserin is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Giddiness, Increased appetite.

Warnings / Precautions

Caution should be done in the patient with bone marrow depression, usually presenting as granulocytopenia or agranulocytosis, has been reporting during treament. If a patient shows fever, sore throat, stomatitis or other signs of infection, treatment should be stopped and a full blood count should be discountinued. Treatment should be discontinued if convulsions or jaundice occurs.

Available Brands

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Single Ingredient

Tabs

10 mg 30 mg

Storage Conditions

Mianserin should be stored Tab .

Drug Classification

1.24.2.1 — Drugs used in depression

Manufacturers

Manufacturers of Mianserin in Pakistan:

Obs