Methylcellulose

Drug #467

Indigestible plant residue used as a lubricating agent in the pharmaceutical preparations and as a purgative. it adsorbs water increases faecal bulk and promotes bowel movement. Methylcellulose is in used in the treatment of diarrhea or constipation and in the treatment of irritable bowel syndrome and spastic colon.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to CHO .

It belongs to Laxatives pharmacological group on the basis of mechanism of action.

pK_a: · Solubility in Water: · Solubility in Alcohol: · Non-proprietary name: Methylcellulose.

Pharmacokinetics

Distribution: Methylcellulose has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is .

Indications

Methylcellulose is primarily indicated in conditions like Constipation, Diarrhoea, Diverticulitis, Irritable bowel syndrome.

Methylcellulose is also indicated for secondary conditions like Obesity.

Contraindications

Methylcellulose is contraindicated in conditions like Intestinal obstruction, Dehydration.

Dosage

Methylcellulose's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
6 g	6 g	Every 24h	PO	Individed doses.
Paediatric Dosage (20kg)
1 g	1 g	Every 12h	Oral	7-12 years
Neonatal Dosage (3kg)
50 mg/kg	50 mg/kg	Every 12h	Oral

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methylcellulose is known to cause more or less tolerable side effects which are usually transient. These include Bloating distension, Diarrhea, Fluid retention, Nausea.

Warnings / Precautions

Methylcellulose should be used only if clearly needed during pregnancy. It should be used with caution in patients with any illness or allergy. It should not be used in Infective bowel disease, Oesophageal obstruction, faecal Impaction.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Eye Drops

0.5 %w/v

Storage Conditions

Methylcellulose should be stored Tab, Caps, Eye Drops, Powder.

Drug Classification

1.21.7 — Other ophthalmologicals

Manufacturers

Manufacturers of Methylcellulose in Pakistan:

Vega