Methyclothiazide

Drug #466

Methyclothiazide is an orally effective diuretic and antihypertensive agent of the thiazide group. It increases the urination and reduces the amount of water and sodium retained by the body. The drugs in this class are formally called benzothiadiazide, usually shortened to thiazides. The nature of the hetrocyclic rings and the substitution on these ring may vary among the congeners but all of them retain a unsubstituted sulfonamide group. Development of thiazides and other modern diuretics began when a perceptive physician noticed that patients receiving sulfanilamide, an early antimicrobial agent, developed metabolic acidosis and a very alkaline urine. Careful study revealed that the drug was causing sodium bicarbonate diuresis. The realization that it could be useful diuretic led first to the development of acetazolamide and then to the thiazides.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzothiadiazine.

It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.

Molecular Weight: 360.25 · pK_a: 9.4 · Solubility in Water: almost insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Methyclothiazide.

Pharmacokinetics

None recorded.

Indications

Methyclothiazide is primarily indicated in conditions like Diabetes insipidus, Edematous states, Heart failure, Hypercalciuric nephrolithiasis, Hypertension.

Contraindications

Methyclothiazide is contraindicated in conditions like Gout, Maturity onset diabetes, Hypersensitivity.

Dosage

Methyclothiazide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.75 mg	3.75 mg	Every 24h	PO	to a maximum of 10 mg
Paediatric Dosage (20kg)
200 ug/kg	200 ug/kg	—
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methyclothiazide in overdosage may give rise to further complications which include Cholestatic jaundice .

Methyclothiazide produces potentially life-threatening effects which include Hyperkalemia , Agranulocytosis, Thrombocytopenia , Blood dyscrasias, Hyponatremia, Aplastic Anemia , Stevens Johnson syndrome, Anaphylaxis , Acute pancreatitis. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Methyclothiazide are Hyponatremia, Hypokalemia , Lethargy, Severe volume depletion, Coma, Hypotension, CNS depression.

Methyclothiazide is known to cause more or less tolerable side effects which are usually transient. These include Gout, Hyperlipidemia, Hyperuricemia , Impotence, Loss of libido.

Warnings / Precautions

Methyclothiazide should be used during pregnancy or lactation only if clearly needed. It should be use with caution in patients with gout or diabetes or any allergies especially to sulfa medications. Avoid any drugs that increase heart rate or cause excitation like decongestants (found in cough and cold products) because it may counter-act blood pressure medicine.Thiazide diuretics increase sensitivity to sunlight, avoid prolonged sun exposure, use sunscreen and wear protective clothing.

Interference in Pathology

Methyclothiazide may interfere in the diagnosis of Serum and urine electrolyte determinations.

Available Brands

None recorded.

Storage Conditions

Methyclothiazide should be stored Tab.

Drug Classification

1.16.1 — Thiazide and related diuretics