Methotrimeprazine (Maleate)
Also known as: Levomepromazine[Maleate]
Methotrimeprazine (Maleate) is antipsychotic with actions, uses and adverse effects similar to Chlorpromazine.it also possess some analgesic and sedating properties perticularly useful in terminal care. Chemically Methotrimeprazine (Maleate) is 2-methoxy-N, N, ß-trimethyl-10H-phenothiazine-10-propanamine. Methotrimeprazine (Maleate) is available in both oral and parentral forms. Methotrimeprazine (Maleate) is also used to treat schizophrenia and agitated depression.
Primary Characteristics
Methotrimeprazine (Maleate) is also known as Levomepromazine[Maleate].
It is of Synthetic origin and belongs to Phenothiazine.
It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Antipsychotic Agent pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 444.5 · pKa: 9.15 · Solubility in Water: slightly soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Methotrimeprazine (Maleate) · pH: 5.4 · Isotonic value: 3.47.
Pharmacokinetics
Absorption: Methotrimeprazine (Maleate) has an pre-systemic (first-pass) metabolism accounts for 25% (±25%).
Distribution: Methotrimeprazine (Maleate) has a volume of distribution is 23-42 l/kg.
Elimination: it is metabolised via Liver, plasma half-life is 15-30 hr.
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Indications
Methotrimeprazine (Maleate) is primarily indicated in conditions like Anxiety, Moderate to severe pain, Psychosis, Schizophrenia.
Contraindications
Methotrimeprazine (Maleate) is contraindicated in conditions like Bone marrow depression, Coma, Heart disease, Close-angle glaucoma.
Dosage
Methotrimeprazine (Maleate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 12.5 – 25 mg | — | Every 6h | IM | severe agitation up to 50mg may be used. |
| 37.5 mg | 37.5 mg | Every 24h | PO | |
| 112.5 mg | 112.5 mg | Every 24h | SC | |
| Paediatric Dosage (20kg) | ||||
| 25 mg | 25 mg | — | Individed doses. | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Methotrimeprazine (Maleate) in overdosage may give rise to further complications which include Tardive dyskinesia , Paralytic ileus , Seizures , Intrahepatic cholestasis , Lens opacities , Maculopathy , Respiratory distress.
Methotrimeprazine (Maleate) produces potentially life-threatening effects which include Agranulocytosis, Neuroleptic Malignant Syndrome . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Methotrimeprazine (Maleate) are Tachycardia , ECG alterations, Hypothermia, Severe extrapyramidal dyskinesias, Drowsiness, Hypotension, Ventricular arrhythmias, Loss of conciousness.
Methotrimeprazine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Contact dermatitis, Dry mouth, Erythematous rash, Head stroke, Hypotension , Parkinsonism, Photosensitivity, Sedation , Weight gain.
Warnings / Precautions
Interference in Pathology
Methotrimeprazine (Maleate) may interfere in the diagnosis of Estimation Tests of serum and urinary Cortisol .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.24.1 — Drugs used in psychotic disorders