Amiloride (HCl)

Also known as: Amipramizide

Drug #46

Amiloride is a potassium sparing diuretic. Amiloride (HCl) is antihypertensive agent. Chemically Amiloride (HCl) is identified as N-Amidino-3, 5-diamino-6-chloropyrazinecarboxamide hydrochloride. It reduces the amount of water and sodium retained by the body. Amiloride (HCl) is used to restore normal serum potassium levels in patients who develop hypokalemia and in patients who would be exposed to a perticular risk if hypokalemia were to develop. Amiloride (HCl) is mostly used in conjunction with other drugs to lower blood pressure.

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Primary Characteristics

Amiloride (HCl) is also known as Amipramizide, Amiloride.

It is of Synthetic origin and belongs to Chloropyrazine.

It belongs to Na channel inhibitor (K-Sparing) pharmacological group on the basis of mechanism of action and also classified in Diuretic Combination pharmacological group.

Molecular Weight: 371.5 · pK_a: 8.7 · Solubility in Water: slightly soluble · Solubility in Alcohol: 1 in 350 · Non-proprietary name: Amiloride (HCl).

Pharmacokinetics

Absorption: Amiloride (HCl) has an oral bioavailability is 50%.

Distribution: Amiloride (HCl) has a volume of distribution is 5 l/kg. plasma protein binding is Low.

Elimination: plasma half-life is 6-9 hr, renal excretion is 50%.

Indications

Amiloride (HCl) is primarily indicated in conditions like Congestive heart failure, Duodenal ulceration, Edema, Hepatic cirrhosis with ascites, Hypertension, Oedema.

Amiloride (HCl) is also indicated for secondary conditions like Cystic fibrosis, NIDDM.

Contraindications

Amiloride (HCl) is contraindicated in conditions like Acute renal failure, Gout, Hyperkalaemia, Diabetic nephropathy.

Dosage

Amiloride (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
35 mg	35 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown9 interactions

7 interactions

Major2 interactions

Moderate3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Amiloride (HCl) in overdosage may give rise to further complications which include Hyperkalemia .

The signs and symptoms that are produced after acute overdosage of Amiloride (HCl) are Dehydration, Electrolyte imbalance .

Amiloride (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Alopecia, Anorexia , Cough , Dizziness, Dyspnea, Flatulence, Headache, Insomnia, Nasal congestion , Nausea, Paresthesias, Polydipsia, Polyuria, Skin rashes, Somnolence , Tinnitus, Tremor, Vertigo, Voice disturbance, Weakness.

Warnings / Precautions

Amiloride should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. Patients should observe caution while driving or performing other activities requiring alertness. Because this drug changes fluid balance, patients may feel dizzy if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. Use with caution during pregnancy or lactation.

Interference in Pathology

Amiloride (HCl) may interfere in the diagnosis of Measurement of serum digoxin levels by immunoassay .

Available Brands

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Multi-Ingredient Combinations

Tabs

5 mg

Storage Conditions

Amiloride (HCl) should be stored Tab.

Drug Classification

1.16.3 — Potassium sparing diuretics

Manufacturers

Manufacturers of Amiloride (HCl) in Pakistan:

Aventis Bosch Dosaco Highnoon Obs Scotmann Werrick