Meptazinol
Meptazinol is opiod agonist -antagonist with partial opiod agonist activity at the u-1opiod receptor; which mimic effects of naturally occuring pain reducing chemicals(endorphins). It also has cholinergic activity. Meptazinol is used orally and parentrally in the treatment of moderate to severe pain.
Primary Characteristics
Meptazinol is also known as Meptazinol (HCl).
It is of Synthetic origin and belongs to Opoid.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic pharmacological group.
Molecular Weight: 269.8 · pKa: 8.7(phenol), 11.9(amino) · Solubility in Water: Very soluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Meptazinol.
Pharmacokinetics
Absorption: Meptazinol has an oral bioavailability is 50% (±50%), pre-systemic (first-pass) metabolism accounts for 46% (±46%).
Distribution: Meptazinol has a volume of distribution is 3.1 l/kg. plasma protein binding is 27%.
Elimination: it is metabolised via Hepatic, plasma half-life is 2 hr, renal excretion is 5%.
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Indications
Meptazinol is primarily indicated in conditions like Acute pain, Chronic pain, Moderate to severe pain, Pain.
Contraindications
Meptazinol is contraindicated in conditions like Hypersensitivity.
Dosage
Meptazinol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 87.5 mg/kg | 87.5 mg/kg | Every 2h | IM | Frequency could be 6 to 12 hourly. |
| 75 mg/kg | 75 mg/kg | Every 2h | IV | Frequency could be 6-12 hourly. |
| 2 mg/kg | 2 mg/kg | Every 4h | PO | For obstetris pain. |
| 200 mg | 200 mg | — | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Meptazinol in overdosage may give rise to further complications which include Hallucinations , Vertigo , Bradycardia , Sweating .
Meptazinol produces potentially life-threatening effects which include Respiratory depression. Careful monitoring is needed with proper medical management.
Meptazinol is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Constipation , Dizziness, Drowsiness, GI disturbance, Nausea, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics