Meprobamate

Drug #450

Meprobamate is a propyl alcohol derivative (propanediol carbamate), having sedative, muscle rexalant and anticonvulsant actions. Meprobamate is effective to relieve anxiety, nervousness, headache and tension.

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Primary Characteristics

It is of Natural origin and belongs to Carbamate.

It belongs to Psychotropic Drugs pharmacological group on the basis of mechanism of action and also classified in Antianxiety Agent pharmacological group.

Molecular Weight: 218.3 · pK_a: 14 · Solubility in Alcohol: 1 in 7 · Non-proprietary name: Meprobamate.

Pharmacokinetics

Distribution: Meprobamate has a plasma protein binding is 20 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 6-17 hr, renal excretion is 65 %.

Indications

Meprobamate is primarily indicated in conditions like Anxiety, Insomnia, Musculoskeletal disorders.

Contraindications

Meprobamate is contraindicated in conditions like Alcohol dependence, Porphyrias, Respiratory depression, Acute pulmonary insufficiency, Breast feeding.

Dosage

Meprobamate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
400 mg	400 mg	Every 8h	PO	Frequency may be increased upto 4 times/day if needed. To maximum of 2.4g.
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Meprobamate in overdosage may give rise to further complications which include Convulsions , Nausea , Vomiting , Tachycardia , Fever , Thrombocytopenia , Hypotension , Angioneurotic edema, Bronchospasm , Hypotension , Bronchospasm , Agranulocytosis , Thrombocytopenic purpura , Chills , parasthesia, Tachycardia.

Meprobamate produces potentially life-threatening effects which include Porpyhria . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Meprobamate are Coma, Shock, Vasomotor collapse, Respiratory collapse.

Meprobamate is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Diarrhea, Dizziness, Drowsiness, Nausea, Sedation , Skin rashes.

Warnings / Precautions

Meprobamate should be used with caution in patients with respiratory disease; muscle weakness; epilepsy,depression (may include seizures); history of drug or alcohol abuse; marked personality disorder; pregnancy; elderly and debilitated; hepatic and renal impairment; avoid prolonged use abrupt withdrawl may precipitate convulsions. DRIVING: Drowsiness may affect performance of skilled tasks (e.g driving); effects of alcohol enhanced.

Interference in Pathology

Meprobamate may interfere in the diagnosis of Test for Barbiturates by Frings TLC Procedure , Test for Oestriol by Brown-Kober Procedure , Test for 17-Ketogenic and 17-Ketosteroids by Zimmerman Reaction , Test for 17-OH Corticosteroids by Glenn-Nelson Method and Porter Silber Reaction .

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Tabs

200 mg

Storage Conditions

Meprobamate should be stored Tab.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders

Manufacturers

Manufacturers of Meprobamate in Pakistan:

Davis Medicaids