Mequitazine

Drug #452

Mequitazine is antihistamine with actions and adverse effects similar to promethazine. Used in the treatment of allergic conditions.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Phenothiazine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 322.5 · pK_a: 8.66 · Solubility in Water: insoluble (4.0le-03g/l) · Solubility in Alcohol: soluble · Non-proprietary name: Mequitazine.

Pharmacokinetics

Absorption: Mequitazine has an oral bioavailability is 70%.

Distribution: Mequitazine has a volume of distribution is 400 litre. plasma protein binding is 90 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 40 hr, renal excretion is 1 %.

Indications

Mequitazine is primarily indicated in conditions like Allergy, Hay fever, Insect bites, Pruritus, Rhinitis, Urticaria.

Mequitazine is also indicated for secondary conditions like Conjuctivitis.

Contraindications

Mequitazine is contraindicated in conditions like Myasthenia gravis, Paralytic ileus, Close-angle glaucoma, Pyloric stenosis, Prostate adenoma, Alcohol abuse, Hypersensitivity to any component of product.

Dosage

Mequitazine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 mg	5 mg	Every 12h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mequitazine is known to cause more or less tolerable side effects which are usually transient. These include Depression, dizziness, Drowsiness.

Warnings / Precautions

Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Mequitazine should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment. Avoid use in young children and use with caution in elderly patients. Topical preparation containing antihistamines should not be used on broken and eczematous skin.

Available Brands

None recorded.

Storage Conditions

Mequitazine should be stored .

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis