Menotrophin
Menotrophin contains follicle stimulating hormone (FSH) and lutenizing hormone (LH) glycoproteins of pituitary origin in a 1:1 ratio. it is prepared from the urine of the postmenopausal women. it is administered intramuscularly. It is used to stimulate ovulation.
Primary Characteristics
It is of Natural origin and belongs to Steroid.
It is classified in Gonadotropin, Ovulation Stimulator pharmacological group. It is also classified under Sex Hormones .
Molecular Weight: 36 · Solubility in Water: soluble · Solubility in Alcohol: Soluble · Non-proprietary name: Menotrophin.
Pharmacokinetics
Absorption: Menotrophin has an oral bioavailability is 15.5% (±4.5%).
Elimination: plasma half-life is 2 hr (FSH), 20 min (LH), renal excretion is 8%.
Advertisement
Indications
Menotrophin is primarily indicated in conditions like Cryptorchidism (undescended testes), Follicular growth stimulation, Hypogonadotrophic hypogonadism, Male infertility, Superovulation.
Contraindications
Menotrophin is contraindicated in conditions like Testicular tumors, Ovarian dysgenesis, Premature menopause, Tubal disease, Testicular failure, Pituitary tumor.
Dosage
Menotrophin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 112.5 IU | 112.5 IU | Every 24h | IM | Dose should be adjusted every 5-7 days. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not indicated in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not use in children | |
Drug Interactions
None recorded.
Side Effects
Menotrophin in overdosage may give rise to further complications which include Pulmonary edema, Gynacomastia , Thromboembolism.
Menotrophin produces potentially life-threatening effects which include Ovarian hyperstimulation syndrome (OHSS). Careful monitoring is needed with proper medical management.
Menotrophin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Fever, Fluid retention, Headache, Joint pain, Mood swings, Tiredness , Weight gain.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.18.6 — Ovulation stimulants