Mefruside
Mefruside is a benzene disulfonamide derivative related to the benzothiadiazine or thiazide diuretics. Mefruside is adminisered orally. Mefruside is used in the treatment of fluid overload and in control of high blood pressure.
Primary Characteristics
It is of Synthetic origin and belongs to Benze Disulfonamide.
It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.
Molecular Weight: 382.9 · pKa: 9.5 · Solubility in Water: practically insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Mefruside.
Pharmacokinetics
Absorption: Mefruside has an oral bioavailability is 60.5% (±9.5%).
Distribution: Mefruside has a volume of distribution is 310-520 litre. plasma protein binding is 64%.
Elimination: plasma half-life is 3-16 hr.
Advertisement
Indications
Mefruside is primarily indicated in conditions like Edema, Hypertension, Oedema.
Contraindications
Mefruside is contraindicated in conditions like Hypercalcaemia, Addison's disease, Hypersensitivity.
Dosage
Mefruside's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 – 50 mg | — | Every 24h | PO | Increase of nessaring to 75-100mg |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mefruside in overdosage may give rise to further complications which include Hyperuricemia, Impaired glucose tolerance, Acute gout.
Mefruside produces potentially life-threatening effects which include Hypokalemia, Hypokalemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Mefruside are Coma, Lethargy, CNS depression.
Mefruside is known to cause more or less tolerable side effects which are usually transient. These include Acute urinary retention, dyspepsia, Hypovolemia, Increased intracranial pressure.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.16.1 — Thiazide and related diuretics