Mecillinam

Drug #440

Mecillinam is a derivative of amidinopenicillanic acid. Unlike benzylpenicillin and related antibiotics, Mecillinam is active against many Gram -ve bacteria in perticular Enterobacteriaceae including Escherichia coli, Enterobacter, Klebsiella, Salmonella and Shigella spp.; Mecillinam is less active against Neisseria spp. and Haemophilus influenzae. It interferes with the synthesis of the bacterial cell wall by binding with a different penicillin-binding protein from benzylpenicillin. Mecillinam is inactivated by beta-lactamases, but is more stable than ampicillin.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Penicillin.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 325.4 · pK_a: 3.4, 8.9 · Solubility in Water: 1 in 1.7 · Solubility in Alcohol: 1 in 40 · Non-proprietary name: Mecillinam.

Pharmacokinetics

Absorption: Mecillinam has an oral bioavailability is 6.5% (±3.5%).

Distribution: Mecillinam has a volume of distribution is 0.3 l/kg. plasma protein binding is 7.5 %.

Elimination: plasma half-life is ~ 1 hr, renal excretion is 60 %.

Indications

Mecillinam is primarily indicated in conditions like Bacterial infections, Enteric fever, UTI.

Contraindications

Mecillinam is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Mecillinam's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.142 mg/kg	0.142 mg/kg	Every 6h	IM	-
300 mg	300 mg	Every 8h	Oral
0.142 mg/kg	0.142 mg/kg	Every 6h	Slow IV	-
Paediatric Dosage (20kg)
10 mg/kg	10 mg/kg	Every 8h	Intra Muscular	-
10 mg/kg	10 mg/kg	Every 8h	Intra Venous	-
Neonatal Dosage (3kg)
10 mg/kg	10 mg/kg	Every 8h	Intra Muscular	-
10 mg/kg	10 mg/kg	Every 8h	Intra Venous	-

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mecillinam is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Nausea, Thrombophlebitis , Vaginitis.

Warnings / Precautions

It should not be given in case of hypersensitivity to penicillins.

Available Brands

None recorded.

Storage Conditions

Mecillinam should be stored Tab.

Drug Classification

1.6.2.1.1 — Penicillins