DrugInfoSys

Mebhydrolin

Drug #439

Mebhydrolin is a sedative anti-histamine with anti-muscarinic properties. Mebhydrolin is used for the symptomatic relief of allergic conditions including urticaria, rhinitis and, in pruritic skin disorders.

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Primary Characteristics

It belongs to Methyl Carboline.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 276.4 · pKa: 6.7 · Solubility in Water: 1 in 1000 · Solubility in Alcohol: 1 in 20 · Non-proprietary name: Mebhydrolin.

Molecular structure of Mebhydrolin

Pharmacokinetics

Absorption: Mebhydrolin has an oral bioavailability is 100%.

Elimination: plasma half-life is 5.5 hr, renal excretion is 0.66 %.

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Indications

Mebhydrolin is primarily indicated in conditions like Allergy, Angioedema, Angiooedema, Eczema, Hay fever, Pruritus, Rhinitis, Urticaria.

Contraindications

Mebhydrolin is contraindicated in conditions like Prostatic hypertrophy, Narrow-angle glaucoma, Hypersensitivity to any component of product.

Dosage

Mebhydrolin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
75 mg75 mgEvery 8hPO
Paediatric Dosage (20kg)
5 mg/kg5 mg/kgEvery 8hOral -
Neonatal Dosage (3kg)
6.25 mg/kg6.25 mg/kgEvery 12hOral

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mebhydrolin in overdosage may give rise to further complications which include Granulocytopenia , Neutropenia , Agranulocytosis .

Mebhydrolin produces potentially life-threatening effects which include Blood dyscrasias. Careful monitoring is needed with proper medical management.

Mebhydrolin is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Sleepiness.

Warnings / Precautions

Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Mebhydrolin should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment.

Interference in Pathology

Mebhydrolin may interfere in the diagnosis of Detection of IgE antibodies for allergy diagnosis .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Susp
50 mg/5ml
Tabs
50 mg

Storage Conditions

Mebhydrolin should be stored .

Drug Classification

  1. 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis

Manufacturers