Medazepam
Medazepam is a benzodiazepine similar to diazepam but less anticonvulsant activity. Medazepam is used in the treatment of anxiety.
Primary Characteristics
It is of Synthetic origin and belongs to Benzodiazepine.
It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group. It is also classified under Sedatives and Hypnotics .
Molecular Weight: 270.8 · pKa: 6.2 · Solubility in Water: almost insoluble · Solubility in Alcohol: 1 in 8 · Non-proprietary name: Medazepam.
Pharmacokinetics
Absorption: Medazepam has an pre-systemic (first-pass) metabolism accounts for 22.5% (±2.5%).
Distribution: Medazepam has a volume of distribution is 0.44 l/kg. plasma protein binding is 99.6 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 36-200 hr, renal excretion is 75 %.
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Indications
Medazepam is primarily indicated in conditions like Anxiety, Insomnia, Muscular contractures.
Medazepam is also indicated for secondary conditions like Alcohol withdrawal, Behavioural disorders, Depression, Epilepsy.
Contraindications
Medazepam is contraindicated in conditions like Depression, Myasthenia gravis, Respiratory insufficiency, Sleep apnea syndrome.
Dosage
Medazepam's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg | 15 mg | Every 24h | PO | Usually in divided doses. Max dose 60 mg/day. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Medazepam are Respiratory arrest.
Medazepam is known to cause more or less tolerable side effects which are usually transient. These include Anterograde amnesia, Drowsiness, Fatigue, Muscular hypotonia, Paradoxical effects, Pruritus , Skin eruptions, Sleepiness.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders
Manufacturers
Manufacturers of Medazepam in Pakistan: