Mebeverine
Mebeverine (HCl) is antispasmodic agent with direct action on the smooth muscle of the gastrointestinal tract. It relieves the abdominal pain and cramps. It was first registered in 1965. Mebeverine (HCl) is administered orally.
Primary Characteristics
Mebeverine is also known as Mebeverine (HCl).
It is of Synthetic origin.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antispasmodic Agent pharmacological group. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .
Molecular Weight: 466 · pKa: 8.1 · Solubility in Water: Very soluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Mebeverine.
Pharmacokinetics
Distribution: Mebeverine has a plasma protein binding is 75%.
Elimination: it is metabolised via Hepatic, plasma half-life is 2.5 hr.
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Indications
Mebeverine is primarily indicated in conditions like Adjunct in GI-disorders, Chronic irritable colon, Gastrointestinal spasm, GIT spasm, Irritable bowel syndrome, Mucous colitis, Spastic colon, Spastic constipation.
Contraindications
None recorded.
Dosage
Mebeverine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 142.5 mg | 142.5 mg | Every 8h | PO | 20 mins before meals, |
| Paediatric Dosage (20kg) | ||||
| 25 mg | 25 mg | — | For 3-4 years | |
| 50 mg | 50 mg | — | For 4-8 years | |
| 100 mg | 100 mg | — | For 8-10 years | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Mebeverine is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Angioedema, Anorexia , Dizziness, Erythematous rash, Gastrointestinal disturbances, Headache, Insomnia.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics