Mebendazole
Mebendazole is a broad spectrum anthelmintic or antiparasitic agent. It was developed in 1972. Chemically Mebendazole is identified as (5-benzoyl-1H-benzimidazol-2-y) carbamic acidmethyl ester. Mebendazole is effective in intestinal worm infections such as pinworm, round worm and hook worm. Mebendazole is administered orally.
Primary Characteristics
It is of Synthetic origin and belongs to Benzimidazol.
It belongs to Fumarate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anthelmintics pharmacological group.
Molecular Weight: 295.3 · Solubility in Water: insoluble · Solubility in Alcohol: insoluble · Non-proprietary name: Mebendazole.
Pharmacokinetics
Absorption: Mebendazole has an oral bioavailability is 7.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 40% (±40%).
Distribution: Mebendazole has a volume of distribution is 1.0-1.2 l/kg. plasma protein binding is 95%.
Elimination: it is metabolised via Hepatic, plasma half-life is 2.8-9 hr, renal excretion is 2-10%.
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Indications
Mebendazole is primarily indicated in conditions like Ascariasis, Capillaria infection, Enterobiasis, Gastric acid reduction (surgical procedures), Giardiasis, Guinea worm infection, Hook worm infection, Hydatid disease, Onchoceriasis, Pin worm infection, Prostate cancer, Roundworm infection, Tapeworm infection, Thread-worm, Thread-worm infection, Trichinosis, Whip worm infection, Whipworm infection.
Contraindications
None recorded.
Dosage
Mebendazole's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mg | 100 mg | Every 12h | PO | For 3 consecutive days. |
| Paediatric Dosage (20kg) | ||||
| 10 mg/kg | 10 mg/kg | Every 12h | Oral | For 3 Days. Not Recommended for Paeds under 2 Yrs |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mebendazole in overdosage may give rise to further complications which include Alopecia , Thrombocytopenia , Bone marrow depression .
Mebendazole produces potentially life-threatening effects which include Leukopenia. Careful monitoring is needed with proper medical management.
Mebendazole is known to cause more or less tolerable side effects which are usually transient. These include Abdominal colic, Diarrhea, Dizziness, Headache, Pyrexia .
Warnings / Precautions
Interference in Pathology
Mebendazole may interfere in the diagnosis of None well documented.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.1.1 — Intestinal anthelmintics