Maprotiline (HCl)

Drug #436

Maprotiline (HCl) is antidepressant, with action and uses and adverse effects similar to imipramine. Maprotiline (HCl) is administered orally.

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Primary Characteristics

It is of Synthetic origin and belongs to Amine.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 313.9 · pK_a: 10.5 · Solubility in Water: slightly soluble · Solubility in Alcohol: soluble · Non-proprietary name: Maprotiline (HCl).

Molecular structure of Maprotiline (HCl)

Pharmacokinetics

Absorption: Maprotiline (HCl) has an oral bioavailability is 50% (±50%).

Distribution: Maprotiline (HCl) has a volume of distribution is 22.6 l/kg. plasma protein binding is ~90%.

Elimination: it is metabolised via Liver 15%, plasma half-life is 27-58 hr, renal excretion is 2%.

Indications

Maprotiline (HCl) is primarily indicated in conditions like Depression.

Contraindications

Maprotiline (HCl) is contraindicated in conditions like Epilepsy, Mania, Myocardial infarction, Urinary retention (adynamic bladder), Narrow-angle glaucoma.

Dosage

Maprotiline (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg	25 mg	Every 24h	PO	Increase by 25 mg every 2 weeks upto 150-225 mg/day.
50 mg	50 mg	Every 24h	PO	once or daily 2-3 divided doses
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

2 interactions

Major5 interactions

Minor2 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Maprotiline (HCl) in overdosage may give rise to further complications which include Cholestatic jaundice , Cholestatic jaundice , Grand-mal seizures , Agranulocytosis , Grand-mal seizures.

The signs and symptoms that are produced after acute overdosage of Maprotiline (HCl) are Coma, Seizures.

Maprotiline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Dizziness, Drowsiness, Dry mouth, faintness, Headache, Hypotension , Palpitation, Skin rashes, Tremors.

Warnings / Precautions

Maprotiline should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures, sunscreen e.t.c, against exposure to UV light or sun light. Following prolong therapy in high doses, abrupt discontinuation of maprotiline should be avoided because it may precipitate the symptoms of the cholinergic rebound such as nausea, vomiting or diarrhea etc. It should be used with extreme caution in case of pre-existing seizures, Parkinsonism, patient with respiratory depression and cardiac diseases. IM injection should be administered with caution in the patient receiving maprotiline. The drug should only be used during pregnancy if clearly needed.

Interference in Pathology

Maprotiline (HCl) may interfere in the diagnosis of None well documented.

Available Brands

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Single Ingredient

Tabs

10 mg 25 mg

Storage Conditions

Maprotiline (HCl) should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression

Manufacturers

Manufacturers of Maprotiline (HCl) in Pakistan:

Indus