Loperamide (HCl)
Loperamide (HCl) is antidiarrheal agent. Loperamide (HCl) is chemically related to haloperidol, acting diractly on the intestinal wall o inhibit paristalsis. It acts mora rapidly and is longer acting than diphenoxylate and cogeine. Loperamide (HCl) is also effective to reduce the amount of discharge from ileostomies. Loperamide (HCl) is prepared by chemical synthesis. Loperamide (HCl) is administered orally.
Primary Characteristics
It is of Synthetic origin and belongs to diphenylbutyramide.
It is classified in Antidiarrhoeals pharmacological group.
Molecular Weight: 513.5 · pKa: 8.7 · Solubility in Water: Soluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Loperamide (HCl).
Pharmacokinetics
Absorption: Loperamide (HCl) has an pre-systemic (first-pass) metabolism accounts for 45.5% (±4.5%).
Distribution: Loperamide (HCl) has a plasma protein binding is 96.5%.
Elimination: it is metabolised via Hepatic (extensively), plasma half-life is 10-12 hr, renal excretion is 0.63-1.4%.
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Indications
Loperamide (HCl) is primarily indicated in conditions like Acute diarrhoea, Chronic diarrhoea in adults, Control of agitated states in elderly without confusion, Diarrhoea, The pain of bowel colic in palliative care.
Contraindications
Loperamide (HCl) is contraindicated in conditions like Acute dysentry.
Dosage
Loperamide (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 10 mg | 10 mg | Every 24h | PO | Followed by 2mg/dose after each stool upto max dose of 16mg/day. |
| Paediatric Dosage (20kg) | ||||
| 0.05 mg/kg | 0.05 mg/kg | Every 6h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Loperamide (HCl) are Constipation, Somnolence, Bradypnea, Muscular hypertonia, Neurological symptoms, Ileus.
Loperamide (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, dizziness, Drowsiness, Fatigue, Nausea, Skin reactions, Urticaria, Vomiting .
Warnings / Precautions
Interference in Pathology
Loperamide (HCl) may interfere in the diagnosis of None well documented.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.17.7.2 — Antidiarrheals