Lisuride

Also known as: Methylergol Carbamide Maleate, Lisuride Maleate, Lysuride

Drug #424

Lisuride is a dopamine receptor agonist. Lisuride is semisynthetic ergot derivative belonging to the 8a-aminoergoline group. Lisuride is effective in the treatment of parkinsons disease especially in the latter stages of disease when the treatment fails.It is reported to have serotonergic activity and has been used in disorders associated with hyperprolactinaemia. Lisuride is not available in any combination preprations. Lisuride is administered orally.

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Primary Characteristics

Lisuride is also known as Methylergol Carbamide Maleate, Lisuride Maleate, Lysuride.

It is of Semi Synthetic origin and belongs to Ergot Alkaloid.

It belongs to D2 agonist pharmacological group on the basis of mechanism of action and also classified in Hormones pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 454.5 · pK_a: 7 · Non-proprietary name: Lisuride.

Pharmacokinetics

Absorption: Lisuride has an oral bioavailability is 50% (±50%), pre-systemic (first-pass) metabolism accounts for 85% (±5%).

Distribution: Lisuride has a volume of distribution is 2.3-2.4 l/kg. plasma protein binding is 70%.

Elimination: plasma half-life is ~8 hr.

Indications

Lisuride is primarily indicated in conditions like Cushing's syndrome, Hyperprolactinaemia, Migraine prophylaxis, Neuroleptic malignant syndrome, Parkinsonism, Parkinson's disease.

Lisuride is also indicated for secondary conditions like Acromegaly, Galactorrhoea.

Contraindications

Lisuride is contraindicated in conditions like Peripheral vascular disease, Pituitary disease, Coronary heart disease.

Dosage

Lisuride's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.002 mg/ kg	0.002 mg/ kg	—	IV	As Required
2.6 mg/day	2.6 mg/day	Every 24h	PO	Initially 0.2mg, increased by 0.2mg weekly until a clinical effect.
0.035 mg/ kg	0.035 mg/ kg	Every 24h	SC
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Lisuride in overdosage may give rise to further complications which include Delirium , Vivid dreams, Confusion , Memory disturbance , Visual hallucination , Drowsiness , Frequent & vivid dreams .

The signs and symptoms that are produced after acute overdosage of Lisuride are Exanthemia, Satyriasis, Hallucinations .

Lisuride is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Dizziness, Itching, Nausea, Vomiting , Weight gain.

Warnings / Precautions

Liver disease may alter the response to drugs in several ways. Prescribing should be kept to a minimum in all patients with severe liver disease, especially if jaundice, ascites, or evidence of encephalopathy present. Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects.

Available Brands

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Single Ingredient

Tabs

0.2 mg

Storage Conditions

Lisuride should be stored Tab.

Drug Classification

1.9.1 — Drugs used in parkinsonism

Manufacturers

Manufacturers of Lisuride in Pakistan:

Bayer