DrugInfoSys

Lindane

Also known as: gamma benzene, Benhexachlor, Gamma benzene hexachloride

Drug #420

Lindane is a gamma isomer of hexachlorocyclohexane. It was commonly called gamma benzene hexachloride which was a misnomer because benzene ring is not present in this compound. Lindane is a powerful parasiticide with a rapid action against the majority of external parasites, including Pediculus humanus var. capitis. Lindane is used topically on skin or hair for lice and scabies. Lindane is only available for topical administeration.

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Primary Characteristics

Lindane is also known as gamma benzene, Benhexachlor, Gamma benzene hexachloride.

It is of Synthetic origin and belongs to Benzene.

It is classified in Antiparasitic pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 290.8 · pKa: not ionizable · Solubility in Water: almost insoluble · Solubility in Alcohol: 1 in 19 · Non-proprietary name: Lindane.

Molecular structure of Lindane

Pharmacokinetics

Elimination: plasma half-life is 21 hr(on the basis of urinary excretion data).

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Indications

Lindane is primarily indicated in conditions like Pediculosis, Scabies.

Contraindications

Lindane is contraindicated in conditions like Seizures, Hypersensitivity, Skin inflammation.

Dosage

Lindane's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
1 %1 %Every 8hTopical As Required
Paediatric Dosage (20kg)
1 %1 %Every 8hTopical As Required
Neonatal Dosage (3kg)
1 %1 %Every 8hTopical As Required

Drug Interactions

None recorded.

Side Effects

Lindane in overdosage may give rise to further complications which include Insomnia , Paresthesia, Giddiness .

Lindane produces potentially life-threatening effects which include Seizures , Aplastic Anemia , Aplastic anemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Lindane are Vomiting, Convulsions , Collapse, Restlessness , Muscular spasm, Loss of equilibrium.

Lindane is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Confusion, Contact dermatitis, Cough , dizziness, Headache, Nausea, Psoriasis , Restlessness, Skin irritation, Vomiting .

Warnings / Precautions

Lindane should not be used in patients with seizure disorders, have open wounds or sores or are allergic to lindane. Elderly persons may be more sensitive to the effects of this medication and a dose reduction may be required. Pregnant women should not be treated more than twice during the pregnancy. Lidane should not be used in neonates, infants 2 years old and younger because of the possibility of high systemic absorption. Children 10 years old and younger also should be treated cautiously with lindane because of an increased potential for toxicity.

Available Brands

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Single Ingredient

Cream
1 %w/w
Lotion
1 %w/v

Storage Conditions

Lindane should be stored Lotion, Cream, Shampoo.

Drug Classification

  1. 1.13.6 — Scabicides & pediculocides

Manufacturers