Liothyronine (Na)

Drug #421

Liothyronine (Na) is a thyroid hormone, probably the active hormone to which thyroxine is converted. Given by mouth or injection it has effect similar to thyroxine but more rapid and short lived. Used when rapid effect is required such as in myxoedema coma.Used with care if there is aevidence of cardiovascular disease as it may precipitate cardiac failure.

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Primary Characteristics

It is of Synthetic origin and belongs to Tyrosine.

It belongs to Thyroxine agonsit pharmacological group on the basis of mechanism of action and also classified in Thyroid Hormone pharmacological group.

Molecular Weight: 650 · pK_a: 2.2, 8.4, 10.1 · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 500 · Non-proprietary name: Liothyronine (Na).

Molecular structure of Liothyronine (Na)

Pharmacokinetics

Absorption: Liothyronine (Na) has an oral bioavailability is 95.5% (±4.5%).

Distribution: Liothyronine (Na) has a plasma protein binding is 99.5%.

Elimination: it is metabolised via Hepatic & Renal, plasma half-life is 1-2 days, renal excretion is By glomerulus filtrate.

Indications

Liothyronine (Na) is primarily indicated in conditions like Diagnostic test for thyroid cancer differentiation, Hypothyroid coma, Hypothyroidism, Hypothyroidism (myxoedema), Myxedema coma.

Contraindications

Liothyronine (Na) is contraindicated in conditions like Adrenal insufficiency, Angina, Cardiac failure.

Dosage

Liothyronine (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
12.5 ug/kg	12.5 ug/kg	Every 12h	IV	Repeated if necessary at 12 hour interval.
15 ug	15 ug	—	Oral	Initial in hypothyeodism.
67.5 ug	67.5 ug	—	Oral	Maintanance in 2 to 3 divided doses up to 100 ug.
Paediatric Dosage (20kg)
0.625 ug/kg	0.625 ug/kg	Every 24h	Oral	Initial
1.25 ug/kg	1.25 ug/kg	Every 8h	Oral	Maintenance , As Required
Neonatal Dosage (3kg)
0.625 ug/kg	0.625 ug/kg	Every 24h	Oral	Initial, Gradually increase to maintenance dose
0.78 ug/kg	0.78 ug/kg	Every 8h	Oral	Maintenance

Drug Interactions

Unknown5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Liothyronine (Na) in overdosage may give rise to further complications which include Tachycardia , Hyperthyroidism , Agitation , Cardiac arrhythmias.

The signs and symptoms that are produced after acute overdosage of Liothyronine (Na) are Thyrotoxicosis .

Liothyronine (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Heat intolerance, Insomnia, Menstrual irregularity, Nervousness, Palpitation, Weight LossX.

Warnings / Precautions

Liothyronine should be used with caution in patients with any heart problems, diabetes, adrenal gland problems or of any allergies, including drug allergies. Avoid using thyroid drugs for weight control. Current information shows that this drug may be used during pregnancy when clearly needed. It should be used with caution during lactation.

Interference in Pathology

Liothyronine (Na) may interfere in the diagnosis of False result of thyroxine level , Supress Radioiodine uptake in normal individual .

Available Brands

None recorded.

Storage Conditions

Liothyronine (Na) should be stored Tab.

Drug Classification

1.18.8 — Thyroid & antithyroid preparations