Lincomycin (HCl)
Lincomycin is an antibiotic produced by a variant of Streptomyces lincolnesis. Lincomycin (HCl) is effective against gram positive bacteria. Lincomycin (HCl) is administered intramuscularly and intravenously. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular intervals of time throughout the day and night as prescribed. Lincomycin (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the therapy it may result in ineffective treatment.
Primary Characteristics
Lincomycin (HCl) is also known as Lincomycin.
It is of Semi Synthetic origin and belongs to Glactoride.
It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.
Molecular Weight: 461 · pKa: 7.6 · Solubility in Water: very soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Lincomycin (HCl) · pH: 4.5 · Isotonic value: 6.6.
Pharmacokinetics
Absorption: Lincomycin (HCl) has an oral bioavailability is 27.5%.
Distribution: Lincomycin (HCl) has a plasma protein binding is 72%.
Elimination: it is metabolised via partially Hepatic, plasma half-life is 4.4 hr, renal excretion is 13%.
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Indications
Lincomycin (HCl) is primarily indicated in conditions like Anaerobic infections, Chronic middle ear infection, Colitis, Impetigo, Osteomyelitis, Pneumonia.
Contraindications
Lincomycin (HCl) is contraindicated in conditions like Hypersensitivity.
Dosage
Lincomycin (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 600 mg | 600 mg | Every 24h | IM | Frequency may be increased upto twice daily if needed. To max at 8g. |
| 600 mg | 600 mg | Every 12h | IV | Frequency may be increased upto 3 times if needed. |
| 500 mg | 500 mg | Every 8h | PO | With empty stomach. Frequency may be increased to 4 times if needed. |
| Paediatric Dosage (20kg) | ||||
| 20 mg/kg | 20 mg/kg | — | Intra Muscular | In divided doses. |
| 60 mg/kg | 60 mg/kg | Every 8h | Oral | |
| 7.5 mg/kg | 7.5 mg/kg | Every 8h | Slow IV | As Required |
| Neonatal Dosage (3kg) | ||||
| 10 mg/kg | 10 mg/kg | — | Intra Muscular | Once in 24 Hours |
| 10 mg/kg | 10 mg/kg | Every 8h | Oral | - |
| 7.5 mg/kg | 7.5 mg/kg | Every 8h | Slow IV | As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Lincomycin (HCl) in overdosage may give rise to further complications which include Thrombocytopenia , Leucopenia, Elevated transaminases , Vaginitis , Pseudomembranous colitis , Angioneurotic edema, Serum sickness , Granulocytopenia , Neutropenia , Erythema multiforme, Glossitis , Apnea.
Lincomycin (HCl) produces potentially life-threatening effects which include Syncope, Hypotension, Anaphylaxis . Careful monitoring is needed with proper medical management.
Lincomycin (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Esophagitis, Fever, Nausea, Perianal irritation, Rectal irritation, Skin rashes, StomatitisX, Tinnitus, Urticaria, Vaginal irritation, VertigoX.
Warnings / Precautions
Interference in Pathology
Lincomycin (HCl) may interfere in the diagnosis of Liver Function Test (LFT) , Periodic blood count.
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.6.2.2.9 — Clindamycin and similar types
Manufacturers
Manufacturers of Lincomycin (HCl) in Pakistan: