Ispaghula

Also known as: Psyllium, Spanish Psyllium seed

Drug #401

Ispaghula consists of dried ripe seeds of Plantago Ovata, Ispaghula is a purgative. Ispaghula adsorbs water and increases the faecal bulk and promotes bowel movement.

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Primary Characteristics

Ispaghula is also known as Psyllium, Spanish Psyllium seed.

It is of Natural origin and belongs to .

It belongs to Laxatives pharmacological group on the basis of mechanism of action.

pK_a: · Solubility in Water: · Solubility in Alcohol: · Non-proprietary name: Ispaghula.

Pharmacokinetics

Distribution: Ispaghula has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is .

Indications

Ispaghula is primarily indicated in conditions like Constipation, Irritable bowel syndrome, Strainous defaecation.

Ispaghula is also indicated for secondary conditions like Chronic renal failure, Hypercholesterolaemia.

Contraindications

Ispaghula is contraindicated in conditions like Intestinal obstruction.

Dosage

Ispaghula's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.5 g	3.5 g	—	PO	For 2-3 days. Should be taken immediately after mixing in at least 150 ml of water or fruit juice.
7 g	7 g	—	PO	for hypercholes terolaemia
Paediatric Dosage (20kg)
300 mg/kg	300 mg/kg	Every 12h	Oral	As Required
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ispaghula in overdosage may give rise to further complications which include Renal pigmentation .

Ispaghula produces potentially life-threatening effects which include Anaphylactic shock, Bronchospasm , Rhinitis . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Ispaghula are Abdominal pain, Intestinal obstruction, Abdominal distension, Flatulence .

Ispaghula is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Flatulence.

Warnings / Precautions

Bulk laxative (ispaghula) should not be given to patients with pre-existing fecal impaction, intestinal obstruction or colonic atony. They should be taken with sufficient fluid and should not be taken immediately before going to bed. They should be avoided to patients who have difficult swallowing. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because may cause allergic reactions (including bronchial asthma). Discontinue use if skin eruption occurs.

Available Brands

None recorded.

Storage Conditions

Ispaghula should be stored Powder.

Drug Classification

1.17.6 — Laxatives