Isoxsuprine

Drug #400

Isoxsuprine is a vasodilator which also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular smooth muscle and its vasodilating action is greater on the artries supplying skeletal muscle than on those supplying skin. It also produces positive inotropic and chronotropic effect. It has been used to arrest premature labour but drugs with a more selective action on beta-2 receptors such as Ritodrine are now generally preferred.

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Primary Characteristics

It is of Synthetic origin and belongs to Adrenaline.

It belongs to Beta adrenergic agonist and alpha antagonist pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group. It is also classified under Calcium Channel Blocker .

Molecular Weight: 337.8 · pK_a: 8.0, 9.8 · Solubility in Water: 1 in 500 · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Isoxsuprine.

Pharmacokinetics

Absorption: Isoxsuprine has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 95%.

Elimination: plasma half-life is 1.5 hr, renal excretion is 74 %.

Indications

Isoxsuprine is primarily indicated in conditions like Arteriosclerosis, Cerebrovascular disease, Premature labour.

Contraindications

Isoxsuprine is contraindicated in conditions like Anaemia, Heart disease, Arterial hemorrhage, Postpartum, Premature detachment of placenta, Hypersensitivity.

Dosage

Isoxsuprine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 mg	10 mg	—	IM	3 to 8 times a day. for maintanace.
200 – 500 ug/min	—	—	IVinf	For arresting premature labouro initialy for 24 hours.
10 – 20 mg	—	—	PO	as avasodilator, 3 or 4 times a day
10 mg	10 mg	—	PO	Prophylaxis.In divided doses.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Isoxsuprine in overdosage may give rise to further complications which include Rashes, Allergic reactions , Fetal Tachycardia.

The signs and symptoms that are produced after acute overdosage of Isoxsuprine are Nausea, Fainting , Light headedness, Weakness .

Isoxsuprine is known to cause more or less tolerable side effects which are usually transient. These include Chest pain, dizziness, Flushed skin, Hypotension , Irregular heart beat, Nausea and vomiting, Pulmonary edema, Rashes , Tachycardia.

Warnings / Precautions

Isoxsuprine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any blood disorders, bleeding episodes or allergies. Cautions should be taken when driving because Isoxsuprine may cause dizziness. Rise slowly from a sitting or lying position to avoid falling.

Available Brands

None recorded.

Storage Conditions

Isoxsuprine should be stored Tab.

Drug Classification

1.12.3.7 — Direct vasodilators
2.22.1.2 — Anti-oxytocics