Isoetharine

Also known as: Ispetarine

Drug #393

Isoetharine is a bronchodialator.It works by relaxing muscles in airways to improve breathing.<BR>Isoetharine (HCl) is a ß-2 selective catecholamine. Chemically Isoetharine (HCl) is (R,S)-4-[1-hydroxy-2-[methylethyl) amino] butyl]-1, 2-benzenediol. Isoetharine (HCl) is used as bronchodialator. It acts on the lung and dilate breathing passages making breathing easier. Isoetharine (HCl) is used to prevent and treat bronchospasm in persons with certain lung diseases. Isoetharine (HCl) is prepared by chemical synthesis and the racemate is used clinically.<BR>Isoetharine (Mesylate) is a beta-adrenergic agonist, the actions and uses similar to those of isoprenaline but with less beta-1 stimulant properties. Isoetharine (Mesylate) is used as a bronchodilator in reversible airways obstructive disease. Isoetharine (Mesylate) is given orally or via inhalation.

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Primary Characteristics

Isoetharine is also known as Ispetarine.

It is of Synthetic origin and belongs to Catecholamine.

It belongs to Beta-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.

Molecular Weight: 239.3 · Solubility in Water: practically insoluble · Solubility in Alcohol: springly soluble · Non-proprietary name: Isoetharine.

Pharmacokinetics

Elimination: it is metabolised via Pulmonary, Hepatic and gastrointestinal, plasma half-life is 24 hr, renal excretion is 10% (unchanged).

Indications

Isoetharine is primarily indicated in conditions like Acute bronchospasm, Asthma, Asthmatic bronchitis, Bronchitis, Chronic obstructive pulmonary disease, Emphysema.

Contraindications

Isoetharine is contraindicated in conditions like Cardiac arrhythmia, Hypertension, Myocardial infarction, Thyrotoxicosis, Ischaemic heart disease, Subvalvular aortic stenosis, Hypersensitivity.

Dosage

Isoetharine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.25 – 1 %	—	—	Inhalation
Paediatric Dosage (20kg)
0 – 0	—	—		Doses not established for this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Isoetharine in overdosage may give rise to further complications which include Breathing difficulty, Extrasystoles , Intolerable muscle tremors , Tachycardia , Palpitation , Headache .

Isoetharine produces potentially life-threatening effects which include Cardiac Arrest , Ventilatory arrest. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Isoetharine are Tremor, Restlessness , Nausea, Tachycardia , B.P. alteration, Excitement, Headache, Anxiety , Dry mouth.

Isoetharine is known to cause more or less tolerable side effects which are usually transient. These include Chest pain, Dizziness, Increase in heart rate , Insomnia, Irregular heart beat, Nausea, Palpitation, Vomiting , Weakness.

Warnings / Precautions

Avoid intraneural or intravascular injection of isoetharine. Avoid situations that may trigger asthmatic attacks such as smoking,dry air etc The drug should be used with caution in the patient with cardiac diseases, AV block associated with digoxin toxicity, narrow-angle glaucoma, shock, during general anesthesia with halogenated agents or cyclopropane, diabetes and in psychoneurotic individuals.

Available Brands

None recorded.

Storage Conditions

Isoetharine should be stored Inhaler.

Drug Classification

1.25.1.2 — Inhalants