Isocarboxazid

Also known as: Marplon

Drug #392

Isocarboxazid is antidepressant and belongs to monoamino oxidase inhibitors. It forms stable complexes with the enzyme, causing irreversible inactivation.This results in increased stores of norepinephrine, serotinin and dopamine within the neuron and subsequent diffusion of excess neurotransmitter into synaptic space.Isocarboxazid is used to treat depression in patient who are unresponsive to tricyclic antidepressant. Isocarboxazid is also used in the treatment of phobic states.

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Primary Characteristics

Isocarboxazid is also known as Marplon.

It is of Synthetic origin and belongs to Hydrazine.

It is classified in Anxiolytics pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 231.3 · pK_a: 10.4 · Solubility in Water: 1 in 2000 · Solubility in Alcohol: 1 in 150 · Non-proprietary name: Isocarboxazid.

Pharmacokinetics

Absorption: Isocarboxazid has an oral bioavailability is 60.5% (±9.5%), pre-systemic (first-pass) metabolism accounts for 60.5% (±9.5%).

Elimination: it is metabolised via Liver, plasma half-life is 36 hr, renal excretion is Urine.

Indications

Isocarboxazid is primarily indicated in conditions like Anxiety, Depression, Narcolepsy, Obsessive-compulsive disorders, Panic disorders, Phobias.

Contraindications

Isocarboxazid is contraindicated in conditions like Phaeochromocytoma, Cardiovascular disease, Cerebrovascular disease.

Dosage

Isocarboxazid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 24h	PO	Up to 40 mg , maintanance
30 mg	30 mg	Every 24h	PO	In single or divided doses up to 60 mg initially.
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown8 interactions

9 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Isocarboxazid in overdosage may give rise to further complications which include Hypertensive crises .

Isocarboxazid produces potentially life-threatening effects which include Purpura , Granulocytopenia . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Isocarboxazid are Hypotension, Tachycardia , Convulsions , Coma, Respiratory depression, Pyrexia, Ataxia, Dizziness, Respiratory depression, Irritability, Mental confusion, Respiratory depression.

Isocarboxazid is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Dizziness, Dry mouth, Edema, Oedema, Orthostatic hypotension, Peripheral edema, Postural dizziness, Slow micturition, Weakness.

Warnings / Precautions

Take adequate precautions when treating epileptic patients. Isocarboxazid should be used with caution in patients with impaired renal (kidney) function and hyperthyroidism. Perform periodic liver function tests, discontinue use at the first sign of hepatic (liver) dysfunction or jaundice.

Available Brands

None recorded.

Storage Conditions

Isocarboxazid should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression