Iopanoic Acid

Drug #387

Iopanoic Acid is iodinated radiographic contrast medium that after oral administration is absorbed from the deudenum, conjugated with glucoronic acid in the liver and secreted in bile. Iopanoic Acid is used as a radiopaque medium in cholecystography and for oral cholangiograghy.

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Primary Characteristics

It is of Synthetic origin and belongs to Iodinated Organic Compounds.

It belongs to Radiopaque Agents pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group.

Molecular Weight: 571 · pK_a: 4.8 · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 2.5 · Non-proprietary name: Iopanoic Acid.

Pharmacokinetics

Absorption: Iopanoic Acid has an oral bioavailability is 103%, pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Distribution: Iopanoic Acid has a plasma protein binding is 79 %.

Elimination: it is metabolised via Hepatic, plasma half-life is ~ 24 hr.

Indications

Iopanoic Acid is primarily indicated in conditions like Cholecystography, Epilepsy (monotherapy), Radiological contrast agent, Vestibular disorders.

Iopanoic Acid is also indicated for secondary conditions like Hyperthyroidism.

Contraindications

Iopanoic Acid is contraindicated in conditions like Cardiovascular disease, Malabsorption.

Dosage

Iopanoic Acid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3 g	3 g	—	PO	Once,as required. Given with plenty of water about 10-14 hours before X-rays.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Iopanoic Acid in overdosage may give rise to further complications which include Thrombocytopenia , Renal impairment , Thyrotoxicosis , Urate nephropathy , Hepatic impairment .

Iopanoic Acid produces potentially life-threatening effects which include Anaphylactoid reactions , Coronary insufficiency, Cardiovascular collapse. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Iopanoic Acid are Diarrhea, Nausea & vomiting.

Iopanoic Acid is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Cramps , Diarrhea, Dizziness, Dysuria, Headache, Heart burn, Hypersensitivity reactions, Nausea and vomiting, Pruritus , Rashes , Sore throat, Urticaria.

Warnings / Precautions

Avoid use of iopanoic acid in patients with severe renal (kidney) or hepatic (liver) disease. Dose higher than 3gm should not be given to patients with renal impairment. Avoid use in presence of acute gastro-intestinal disease, as it may impair the absorption. It should be used with caution in patients with history of hypersensitivity to iodine, or other contrast media, hyperthyroidism, hyperuricaemia.

Interference in Pathology

Iopanoic Acid may interfere in the diagnosis of Thyroid Function Test , False +ver result of Sulphosalicylic acid test , Pisano Test , Serum Urate Measurement , Increases Sulphobromophthaline retention , Increases Serum Bilirubin .

Available Brands

None recorded.

Storage Conditions

Iopanoic Acid should be stored Tab.

Drug Classification

1.14.2 — Radiocontrast media