Iodine Compounds

Drug #385

Iodine and iodine releasing agents are widely used as topical broad spectrm antiseptics and as disinfectant and sanitizers. Elemental iodine was discovered in 1811 and is ablack blue material. Elemental iodine is highly irritant and corrosive but formulation as an iodophor greatly reduces these unwanted adveres effects.

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Primary Characteristics

It is of Natural origin and belongs to Iodides.

It belongs to Dermatological-Antiseptic pharmacological group on the basis of mechanism of action and also classified in Counter Irritant pharmacological group. It is also classified under Antiseptics and Germicides .

Molecular Weight: 253.8 · pK_a: 0.75 · Solubility in Water: 1 in 3000 · Solubility in Alcohol: 1 in 13 · Non-proprietary name: Iodine Compounds.

Pharmacokinetics

None recorded.

Indications

Iodine Compounds is primarily indicated in conditions like Acne vulgaris, Bladder irrigation, Burns, Hyperthyroidism, Incisions, Minor injuries, Pharyngitis, Skin infections, Stomatitis, Thyroid gland radiation protection, Thyroid involution, Ulcers, Vaginal infections.

Contraindications

Iodine Compounds is contraindicated in conditions like Conception, Local sensitization.

Dosage

Iodine Compounds's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 – 2.5 %	—	—	Topical	As required.As anantiseptic & disinfectant.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Iodine Compounds in overdosage may give rise to further complications which include Goitre , Iodism, Gi bleeding , Thyroid adenoma, Infant hypothyroidism .

Iodine Compounds produces potentially life-threatening effects which include Neutropenia . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Iodine Compounds are Circulatory failure, Purging , Abdominal pain, Diarrhea, Nausea & vomiting, Thirst .

Iodine Compounds is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Fever, Joint pain, Skin rashes, Slivary gland swelling, Staining of skin & clothes.

Warnings / Precautions

Caution is necessary if preparations containing iodine or iodides are taken for prolong periods and such preparation should not be taken regularly during pregnancy except when iodine supplementation is required. Iodine should not be given to the nursing mother and caution is also required when given to the children. Patients over the age of 45 years or with nodular goitres are specially susceptible to hyperthyroidism. Solution of iodine applied to the skin should not be covered with occlusive dressing . It should be used with caution in patient with cardiac disease or renal (kidney) impairment.

Interference in Pathology

Iodine Compounds may interfere in the diagnosis of Thyroid Funtion Test.

Available Brands

None recorded.

Storage Conditions

Iodine Compounds should be stored Tincture, Oint, Cream, Gargle, Dry Powder Sprays, Vag suppositories, Vag Gel.

Drug Classification

1.15 — Disinfectants and antiseptics