Iodine

Drug #384

Iodine and Iodine releasing agents are widely used as topical broad spectrm antiseptics and as disinfectant and sanitizers. Elemental Iodine was discovered in 1811 and is ablack blue material. Elemental Iodine is highly irritant and corrosive but formulation as an iodophor greatly reduces these unwanted adveres effects. In body Iodine is used in the production of thyroid hormone. When the gland is overactive Iodine is given orally to suppress thyroid function prior to surgical removal of thyroid tissue

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Primary Characteristics

Iodine is also known as Iodine Compounds, Iodine Methyl Salisylate.

It is of Natural origin and belongs to Iodide.

It belongs to Minerals and Electrolytes pharmacological group on the basis of mechanism of action. It is also classified under Antiseptics and Germicides .

Molecular Weight: 166 · pK_a: Completely Ionized · Solubility in Water: 1 in 0.7 · Solubility in Alcohol: 1 in 23 · Non-proprietary name: Iodine.

Pharmacokinetics

Absorption: Iodine has an oral bioavailability is 95% (±5%).

Distribution: Iodine has a volume of distribution is 0.3 l/kg.

Indications

Iodine is primarily indicated in conditions like Hyperthyroid crisis, Hyperthyroidism, Sporotrichosis, Thyroid involution induction, Thyrotoxicosis.

Iodine is also indicated for secondary conditions like Thyroidectomy.

Contraindications

Iodine is contraindicated in conditions like Asthma, Hyperkalaemia, Acne vulgaris, Tuberculosis, Goiter, Bronchitis, Vasculitis, Thomsen's disease, Hypersensitivity.

Dosage

Iodine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.25 %	2.25 %	Every 8h		Antiseptic & dirinfactant.
0.086 mg/ kg	0.086 mg/ kg	Every 8h	PO
0.2 ml	0.2 ml	—	PO	Should be taken with water or milk. as recommended
Paediatric Dosage (20kg)
0.3 ml	0.3 ml	—
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Iodine in overdosage may give rise to further complications which include Eosinophilia , Eosinophilia , Hypothyroidism , Goitre , Goitre.

Iodine produces potentially life-threatening effects which include Neutropenia . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Iodine are Vomiting, Diarrhea, Coma, Fever, Delirium, Renal failure, Abdominal pain, Ventricular arrhythmias, Metallic taste, Lactic acidosis.

Iodine is known to cause more or less tolerable side effects which are usually transient. These include Arthralgia, Bronchitis , Conjunctivitis, Coryza, Enlargement of salivary gland, Headache, Iodine toxicity, Salivation , Skin rashes, Sneezing, Urticaria, Vasculitis.

Warnings / Precautions

Observed patients closely for acute iodide toxicity, if symptoms appear discontinue the therapy. It should be used with caution in patient with hyperthyroidism, cardiac disease or renal (kidney) impairment. Prolong use during pregnancy is not advised.

Interference in Pathology

Iodine may interfere in the diagnosis of Thyroid Function Test by supressing radio-iodine uptake from thyroid gland. .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

300 mg/ml 350 mg/ml 370 mg/ml

Oint

5 %w/w

Scrub

7.5 %w/v

Soln

0.75 %w/v 1 %w/v 1 mg 2 mg 7.5 %w/v 76 %w/v

Multi-Ingredient Combinations

Caps

0.15 mg

Caps

100 mcg 100 mg 140 mcg 200 mcg

Comp Oint

Drops

Oint

Paint

Soln

Syrup

150 mcg/5ml 25 mcg/5ml 50 mcg/5ml 75 mcg/5ml

Tabs

0.75 mg 100 mcg 150 mcg 150 mgc 50 mcg 75 mcg

Tinc

2 %w/v

Storage Conditions

Iodine should be stored Soln.

Drug Classification

1.14.2 — Radiocontrast media
2.15 — Disinfectants and antiseptics
3.27 — Vitamins, minerals, tonics, and other susbstances

Manufacturers

Manufacturers of Iodine in Pakistan: