Hyaluronidase
Hyaluronidase is enzyme that catalyzes the breakdown of hyaluronic acid. Hyaluronidase is found in the mammalian testicular and spleen tissues, in bees and snake venoms and in certain species of Clostridium, Staphylococcus and Streptococcus. Hyaluronidase is used clinically to facilitate the administration of fluid by hypodermoclysis. Hyaluronidase is used to render the tissues more readily pormeable to injected fluids e.g for introduction of fluids by sub-cutaneously infusion.
Primary Characteristics
It is of Natural origin and belongs to CHO.
It belongs to Hyaluronidase Enzyme pharmacological group on the basis of mechanism of action and also classified in Enzyme pharmacological group. It is also classified under Antidotes .
Molecular Weight: 6100000000 · pKa: 8.6 0000000 · Solubility in Water: readily soluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Hyaluronidase.
Pharmacokinetics
Elimination: it is metabolised via Hepatic, plasma half-life is 3.2 min, renal excretion is partial.
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Indications
Hyaluronidase is primarily indicated in conditions like Bleeding from oesophageal varices, Enhance permeation of SC or IM inj, Extravasation/haematoma, Local anaesthesia, Permeation of injections, Primary nocturnal enuresis, Prophylaxis of vascular headache, Treatment of osteoporosis in post menopausal women.
Hyaluronidase is also indicated for secondary conditions like Arachnoiditis, Myocardial infarction, Peripheral circulatory disorders.
Contraindications
Hyaluronidase is contraindicated in conditions like Infections.
Dosage
Hyaluronidase's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1500 IU | 1500 IU | — | IM,SC | Per Infusion or As Required |
| Paediatric Dosage (20kg) | ||||
| 1500 IU | 1500 IU | — | Intra Muscular | Total Dose |
| Neonatal Dosage (3kg) | ||||
| 1500 IU | 1500 IU | — | Intra Muscular | Total Dose |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Hyaluronidase produces potentially life-threatening effects which include Hypersensitivity reactions, Anaphylactic shock. Careful monitoring is needed with proper medical management.
Hyaluronidase is known to cause more or less tolerable side effects which are usually transient. These include Bleeding , Bruising , Edema, Local irritation.
Warnings / Precautions
Interference in Pathology
Hyaluronidase may interfere in the diagnosis of None well documented.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.21.7 — Other ophthalmologicals
Manufacturers
Manufacturers of Hyaluronidase in Pakistan: