Human Insulin
Also known as:
Insulin is a small protein. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. Human Insulin is produced by semisynthetic and recombinant DNA techniques. In 1921, Banting and Best extracted insulin from the pancrease and demonstrated its therapeutic effects in diabetic dogs and human subjects. its appears to be as effective as conventional animal insulins, it appears to be considerably less immunogenic in diabetes patients than beef-pork insulins.
Primary Characteristics
Human Insulin is also known as .
It is of Natural origin and belongs to Polypeptide.
It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.
Molecular Weight: 5777.6 · Solubility in Water: slight · Solubility in Alcohol: very low · Non-proprietary name: Human Insulin.
Pharmacokinetics
Absorption: Human Insulin has an oral bioavailability is 1% (±1%), pre-systemic (first-pass) metabolism accounts for 100%.
Distribution: Human Insulin has a volume of distribution is 5 ml/kg. plasma protein binding is 5%.
Elimination: it is metabolised via Hepatic and Renal, plasma half-life is 3-5 min, renal excretion is 20%.
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Indications
Human Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia, Iddm.
Contraindications
None recorded.
Dosage
Human Insulin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6 IU | 6 IU | Every 24h | IM | hourly |
| 20 IU | 20 IU | Every 24h | IM | Initially |
| 0.1 – 0.4 IU/ kg | — | Every 24h | IV | Dose depends upon blood sugar level |
| 10 IU | 10 IU | Every 24h | SC | In divided doses. Dose depends upon blood sugar level |
| Paediatric Dosage (20kg) | ||||
| 0.375 IU/kg | 0.375 IU/kg | Every 24h | Subcutaneous | - |
| Neonatal Dosage (3kg) | ||||
| 0.375 IU/kg | 0.375 IU/kg | Every 24h | Subcutaneous | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Human Insulin produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia, Hypoglycemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Human Insulin are Hypokalemia .
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.18.7.1 — Insulins