Human Anti-D Immunoglobulin

Drug #359

Human Anti-D Immunoglobulin is used to prevent a Rh-ve mother actively forming antibodies to fetal Rh+ve red blood cells that may pass into maternal circulation during childbirth, abortion or other sensitizing events.

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Primary Characteristics

It is of Natural origin.

It belongs to Antibody pharmacological group on the basis of mechanism of action and also classified in Immune Globulin pharmacological group. It is also classified under CDC Biologicals .

Non-proprietary name: Human Anti-D Immunoglobulin.

Molecular structure of Human Anti-D Immunoglobulin

Pharmacokinetics

Elimination: it is metabolised via in Plasma & IF, plasma half-life is 21 days(IgG1).

Indications

Human Anti-D Immunoglobulin is primarily indicated in conditions like Idiopathic thrombocytopenic purpura, Rhesus haemolytic disease.

Contraindications

Human Anti-D Immunoglobulin is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Human Anti-D Immunoglobulin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 – 1500 IU	—	—	IM	As Required
Paediatric Dosage (20kg)
300 Units/kg	300 Units/kg	—		Idtopathic theombocytopenic purpuron.
250 units/kg	250 units/kg	—	IV	Idtopathic theombocytopenic purpuron.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Human Anti-D Immunoglobulin in overdosage may give rise to further complications which include Hemorrhage.

Human Anti-D Immunoglobulin produces potentially life-threatening effects which include Anaphylactoid reactions , Hypotension, Collapse , Chest pain. Careful monitoring is needed with proper medical management.

Human Anti-D Immunoglobulin is known to cause more or less tolerable side effects which are usually transient. These include Chills, Flushing, Headache, Nausea.

Warnings / Precautions

Anti-D immunoglobulin should be administered with caution to Rh +ve person for the treatment of blood disorder.

Interference in Pathology

Human Anti-D Immunoglobulin may interfere in the diagnosis of Positive direct antiglobulin test .

Available Brands

None recorded.

Storage Conditions

Human Anti-D Immunoglobulin should be stored Inj.

Drug Classification

1.19.2.1 — Anti-D immunoglobulins (human)