DrugInfoSys

Human Albumin

Drug #358

Human Albumin is a sterile, nonpyrogenic preparation of serum albumin obtained by fractionating blood, plasma, serum or placentas from healthy human donors. It maintains the blood volume. Human Albumin is used as plasma volume expander in the treatment of shock, burns and low level of blood protein to correct or prevent deficiency of blood volume. Human Albumin is aministered intravenously. It solutions were developed by the Cohn and his associates during the Second World War, specifically to provide an improved material for emergency transfusion to military casualties. A method was developed to produce relatively pure albumin solutions from large quantities of human plasma and this stil remains the basis of virtually all production of clinical albumin products.

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Primary Characteristics

It is of Natural origin and belongs to Protein.

It is classified in Blood Product Deriv, Plasma Vol Expand, Colloid pharmacological group.

Molecular Weight: 66300 · Non-proprietary name: Human Albumin.

Molecular structure of Human Albumin

Pharmacokinetics

Elimination: plasma half-life is 3-24 hr.

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Indications

Human Albumin is primarily indicated in conditions like Burns, HIV infection, Hypoalbuminaemia, Hypovolaemia, Shock.

Human Albumin is also indicated for secondary conditions like Adult respiratory distress syndrome (ards).

Contraindications

Human Albumin is contraindicated in conditions like Congestive heart failure.

Dosage

Human Albumin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
25 g/ kg/dose25 g/ kg/doseEvery 24hIVRepeat every 1-2 days. Usual dose 25g. No more than 250g should be administered within 48 hours. Maximum dose 2g/kg/dose
150 ml150 ml—IV-inf1-2 ml/min, of 25 % solution.
Paediatric Dosage (20kg)
5 ml/kg5 ml/kgEvery 24hIntra Venous InfusionInfuse over 30-60 Min
Neonatal Dosage (3kg)
375 mg/kg375 mg/kgEvery 24hInfusionOver 30 to 60 minutes

Drug Interactions

None recorded.

Side Effects

Human Albumin in overdosage may give rise to further complications which include Oedema .

Human Albumin produces potentially life-threatening effects which include Severe Hypotension , Severe hypotension, Transmission of infectious agent. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Human Albumin are Hypotension, Volume overload.

Human Albumin is known to cause more or less tolerable side effects which are usually transient. These include Chills, Fever, Nausea and vomiting, Urticaria.

Warnings / Precautions

Albumin should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing heart disease, kidney disease, liver disease, blood disorders, anemia or any allergy especially to protein

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inf
20 %w/v
Inj
20 %w/v25 %w/v
Inj-IV
20 %w/v

Storage Conditions

Human Albumin should be stored . Inj.

Drug Classification

  1. 1.11.1 — Plasma substitutes

Manufacturers

Manufacturers of Human Albumin in Pakistan:

ETDCGenesisHakimsonsIBLNabiqasimNovoPopular Int.S.Ejazuddin