Homatropine (HBr)

Drug #357

Homatropine (HBr) is the hydrobromide salt of homatropine which is atropine ester of mendelic acid, having anticholinergic effects similar to atropine but weaker than atropine. Homatropine (HBr) is used as a mydriatic. Homatropine (HBr) is relaxes the eye muscles and causing the pupil to dilate. italso used during eye examinations.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Tertiary Amine .

It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Mydriatic pharmacological group. It is also classified under Opthalmic Products .

Molecular Weight: 356.3 · pK_a: 9.9 · Solubility in Water: 1 in 6 · Solubility in Alcohol: 1 in 60 · Non-proprietary name: Homatropine HBr · pH: 5 · Isotonic value: 5.67.

Molecular structure of Homatropine (HBr)

Pharmacokinetics

Distribution: Homatropine (HBr) has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is .

Indications

Homatropine (HBr) is primarily indicated in conditions like Cycloplegia induction, Glucoma, Induce cycloplegia, Induce mydriasis, Mydriasis induction, Uveitis.

Contraindications

Homatropine (HBr) is contraindicated in conditions like Narrow-angle glaucoma.

Dosage

Homatropine (HBr)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.001 mg	0.001 mg	—	Ophthalmic	As Required
1285 %	1285 %	—	Ophthalmic	Every 5-10 Minutes, As Required. To be given as drops.
Paediatric Dosage (20kg)
2 %	2 %	Every 12h	Opthalmic	Older children
Neonatal Dosage (3kg)
1.5 %	1.5 %	—	Opthalmic	As Required

Drug Interactions

Unknown5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Homatropine (HBr) in overdosage may give rise to further complications which include Posterior synechia.

Homatropine (HBr) produces potentially life-threatening effects which include Coma, Convulsions , Respiratory Failure , Respiratory failure. Careful monitoring is needed with proper medical management.

Homatropine (HBr) is known to cause more or less tolerable side effects which are usually transient. These include Bloated feeling, Brow ache, Conjunctivitis, Contact dermatitis, dizziness, Drowsiness, Flushing, Headache, Hypersensitivity reactions, Insomnia, Lacrimation, Loss of taste, Nervousness, Pain , Photophobia , Weakness.

Warnings / Precautions

Homatropine should be used with caution in patients with glaucoma. Do not use this medication while wearing soft contact lenses because the lenses may be discolored. This medication should be used during pregnancy only if clearly needed.should be used with cuation in pateints with fever.

Available Brands

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Single Ingredient

Eye Drops

2 %w/v

Storage Conditions

Homatropine (HBr) should be stored Eye Drops.

Drug Classification

1.21.5 — Mydriatics, Cycloplegics

Manufacturers

Manufacturers of Homatropine (HBr) in Pakistan:

Ethical