Hexobarbitone (Na)
Also known as: Hexobarbital Na
Hexobarbitone (Na) is a hypnotic and effective in treating insomnia.
Primary Characteristics
Hexobarbitone (Na) is also known as Hexobarbital Na.
It is of Synthetic origin and belongs to Barbiturate.
It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action. It is also classified under General Anesthetics .
Molecular Weight: 258.3 · pKa: 8.2 · Solubility in Water: > 1 in 1 · Solubility in Alcohol: > 1 in 1 · Non-proprietary name: Hexobarbitone (Na).
Pharmacokinetics
Absorption: Hexobarbitone (Na) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 5% (±5%).
Distribution: Hexobarbitone (Na) has a volume of distribution is 1.1 l/kg. plasma protein binding is 48%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 4.4 hr, renal excretion is major.
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Indications
Hexobarbitone (Na) is primarily indicated in conditions like Insomnia.
Contraindications
Hexobarbitone (Na) is contraindicated in conditions like Anaemia, Septicaemia, Cancer, Liver diseases, Ileus hyperemesis.
Dosage
Hexobarbitone (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5.356 mg/kg | 5.356 mg/kg | — | IV | Once or As Required |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Hexobarbitone (Na) in overdosage may give rise to further complications which include Grand-mal seizures , Abstinence syndrome , Grand-mal seizures.
Hexobarbitone (Na) produces potentially life-threatening effects which include Bronchospasm , Bronchospasm, Fall in B.P. , Laryngospasm , Coughing, Respiratory difficulties, Tissue damage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Hexobarbitone (Na) are Hypotension, Death , Respiratory depression, Respiratory depression, Renal failure, Poisoning , Peripheral vascular collapse, Feeble heart beat, Lowered body temperature, Respiratory depression.
Hexobarbitone (Na) is known to cause more or less tolerable side effects which are usually transient. These include Allergic skin reactions, Ataxia, CNS depression, Drowsiness, Hangover , Headache, Lethargy, Nystagmus , Sedation , Slurred speech.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors