Heparin (Na) and Heparin (Cl)
Heparin (Na) and Heparin (Cl) is anticoagulant agent. Heparin (Na) and Heparin (Cl) is a highly negatively charged heterogeneous mixture of sulfated mucopolysaccharide, varying in the molecular weights and composed of polymer of alternating derivatives of D-glucosamine and L-iduronic acid or D-glucuronic acid, having the property of prolonging the clotting time of blood. Heparin is the body's natural anticoagulant. Heparin (Na) and Heparin (Cl) is usually obtained from the lungs, intestinal mucosa or other suitable tissue of domestic mammals used for food by man. Heparin is employed clinically in conditions in which a rapid reduction in the coagulation ability of blood is desired. Heparin calcium and heparin sodium are the calcium and sodium salts of active principles that compose heparin. Heparin calcium and sodium are administered intravenously or subcutaneously.
Primary Characteristics
Heparin (Na) and Heparin (Cl) is also known as Heparinoids, Heparin (Na).
It is of Natural origin and belongs to Mucopolysaccharides.
It belongs to Blood Coagulation pharmacological group on the basis of mechanism of action and also classified in Anti Acne , Anticoagulants pharmacological group. It is also classified under Anticoagulants .
Molecular Weight: 16500 · pKa: low · Solubility in Water: 1 in 20 · Solubility in Alcohol: very low · Non-proprietary name: Heparin (Na) and Heparin (Cl).
Pharmacokinetics
Distribution: Heparin (Na) and Heparin (Cl) has a volume of distribution is 0.037-0.072 l/kg. plasma protein binding is 95%.
Elimination: it is metabolised via Hepatic, plasma half-life is 23 min-2.48 hr (depend on the dose), renal excretion is partial.
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Indications
Heparin (Na) and Heparin (Cl) is primarily indicated in conditions like Analgesia, Angina, Consumptive thrombohemorrhagic disorders, Deep vein thrombosis, During pregnancy, Maintenance of light anaesthesia, Metastatic germ cell cancers (seminoma and teratoma), Myocardial infarction, Prophylaxis of thrombosis, Pulmonary embolism, Treatment of deep-vein thrombosis and pulmonary embolism.
Contraindications
Heparin (Na) and Heparin (Cl) is contraindicated in conditions like Subarachnoid haemorrhage, Renal failure, Haemostatic defect, Hepatic failure, Cerebral hemorrhage, Arterial thrombosis, Wounds, Abdominal bleeding.
Dosage
Heparin (Na) and Heparin (Cl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5000 IU | 5000 IU | Every 12h | IV | For treatment of deep vein thrombosis. |
| 1000 – 2000 unit/hr | — | — | IV-Inf | followed after IV-inj. |
| 12 IU | 12 IU | Every 12h | SC | For prophylaxis of deep vein thrombosis. For 10 days after IV administration in myocardial infaction. |
| 0.3 % | 0.3 % | Every 6h | Topical | |
| Paediatric Dosage (20kg) | ||||
| 25 IU/kg.hr | 25 IU/kg.hr | — | IV Infusion | As Required |
| Neonatal Dosage (3kg) | ||||
| 25 IU/kg.hr | 25 IU/kg.hr | — | IV Infusion | As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Heparin (Na) and Heparin (Cl) in overdosage may give rise to further complications which include Skin necrosis , Hypoaldosteronism , Osteoporosis .
Heparin (Na) and Heparin (Cl) produces potentially life-threatening effects which include Thrombocytopenia , Bleeding . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Heparin (Na) and Heparin (Cl) are Bleeding .
Heparin (Na) and Heparin (Cl) is known to cause more or less tolerable side effects which are usually transient. These include Anaphylactic shock, Angioedema, Asthma, Conjunctivitis, Cyanosis, Delayed-type hypersensitivity, Oppressive feelings, Rhinitis , Tachypnea, Urticaria.
Warnings / Precautions
Interference in Pathology
Heparin (Na) and Heparin (Cl) may interfere in the diagnosis of Thyroid Function Test, Benzodiazepine Estimations , Propranalol Estimations .
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.10.2 — Anticoagulants/Platelet deaggregators
- 2.17.3 — Antihemorrhoidals