DrugInfoSys

Griseofulvin

Also known as: Curling Factor

Drug #350

Griseofulvin is antifungal agent produced by Pencillium griseofulvum. It acts as a fungistatic. It has been largely replaced by a newer antifungal medications such as itraconazole and terbinafine.

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Primary Characteristics

Griseofulvin is also known as Curling Factor.

It is of Natural origin and belongs to Benzofuran.

It is classified in Antifungals pharmacological group.

Molecular Weight: 352.8 · Solubility in Water: 1 in 1000 · Solubility in Alcohol: 1 in 300 · Non-proprietary name: Griseofulvin.

Molecular structure of Griseofulvin

Pharmacokinetics

Distribution: Griseofulvin has a volume of distribution is 1.305 l/kg.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 9.5-21 hr, renal excretion is 50%.

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Indications

Griseofulvin is primarily indicated in conditions like Dermatophytic infections, Fungal infection, Parkinson's disease.

Contraindications

Griseofulvin is contraindicated in conditions like Systemic lupus erythematosus, Porphyrias, Hepatic failure.

Dosage

Griseofulvin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
750 mg750 mgEvery 24hPO
Paediatric Dosage (20kg)
10 mg/kg10 mg/kgEvery 24hOral -
Neonatal Dosage (3kg)
10 mg/kg10 mg/kgEvery 24hOral

Drug Interactions

Unknown15 interactions
Minor1 interaction
Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Griseofulvin produces potentially life-threatening effects which include Angioedema . Careful monitoring is needed with proper medical management.

Griseofulvin is known to cause more or less tolerable side effects which are usually transient. These include Cholestasis, Diarrhea, Drug eruptions, Leprosy , Nausea, Severe headache, Urticaria.

Warnings / Precautions

Avoid alcoholic beverages while taking Griseofulvin unless doctor gives permission, drinking alcohol during treatment with this drug could result in a rapid heart rate and flushing of the skin. It should be used cautiously during pregnancy only if clearly needed. Griseofulvin may increase sensitivity to sunlight, so wear protective clothing and an appropriate sunscreen or avoid sun lamps.

Available Brands

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Single Ingredient

Susp
125 mg/5ml
Tabs
125 mg500 mg

Storage Conditions

Griseofulvin should be stored Tab.

Drug Classification

  1. 1.6.3 — Antifungal drugs

Manufacturers