Goserelin (Acetate)

Drug #347

Goserelin (Acetate) is anticancer agent, also called as antineoplastic drug. Goserelin (Acetate) is a synthetic peptide analoge of naturally occuring gonadotrophin releasing hormone. Goserelin (Acetate) is more potent than the natural hormone, has longer duration of action, and function as gonadotrophin releasing hormone agonist.

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Primary Characteristics

It is of Synthetic origin and belongs to Peptide.

It belongs to LH-RH agonist pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Miscellaneous pharmacological group.

Molecular Weight: 1269.4 · pK_a: 6.2 · Solubility in Water: high · Solubility in Alcohol: low · Non-proprietary name: Goserelin (Acetate).

Molecular structure of Goserelin (Acetate)

Pharmacokinetics

Distribution: Goserelin (Acetate) has a volume of distribution is 13.7 litre.

Elimination: it is metabolised via by Cell Peptidases, plasma half-life is 4.2 hr, renal excretion is 790%.

Indications

Goserelin (Acetate) is primarily indicated in conditions like Advanced breast cancer( er+ve early breast cancer), Before surgery in women who have anaemia due to uterine fibroids, Breast cancer and prostate cancer, Endometrial thinning before intra-uterine surgery, Endometriosis, Pituitary desensitisation, Prostate cancer, Prostatic cancer, Uterine fibroids.

Contraindications

None recorded.

Dosage

Goserelin (Acetate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.6 mg	3.6 mg	—	SC	Every 28th days treatement is continued with repeated doses at 28 day interval for upto 6 months
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Goserelin (Acetate) in overdosage may give rise to further complications which include Spinal cord compression , Ureteric obstruction .

Goserelin (Acetate) produces potentially life-threatening effects which include Hypertestosteronemia, Elevated serum testosterone. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Goserelin (Acetate) are Elevated serum testosterone.

Goserelin (Acetate) is known to cause more or less tolerable side effects which are usually transient. These include Anaphylaxis, Bone pain, Hot flushes, Pruritis, Urticaria, Withdrwal bleeding.

Warnings / Precautions

Goserelin should be used with caution in patients with history especially of any undiagnosed vaginal bleeding, urination problems, spinal cord problems and of any drug allergies. It is not recommended for use during pregnancy or lactation.polycystic overy disease, diabetes, ureteric obstruction. pinal cordcompression in men.

Interference in Pathology

Goserelin (Acetate) may interfere in the diagnosis of Elevations of SGPT and SGOT , Gonadotrophin Test , Elevation in ALT or AST.

Available Brands

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Single Ingredient

Inj

3.6 mg

Storage Conditions

Goserelin (Acetate) should be stored Inj.

Drug Classification

1.18.6 — Ovulation stimulants

Manufacturers

Manufacturers of Goserelin (Acetate) in Pakistan:

ICI