Gonadorelin (HCl)

Drug #346

Gonadorelin (HCl) is the mono or dihydrochloride salt of gonadorelin which is a synthetic form of hypothalamic gonadotrophin-releasing hormone, structurally identical to the natural hormone. Gonadorelin (HCl) is used in the treatment of amenorrhea and infertility due to ovarian hormone deficiency.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Peptide.

It belongs to LH-RH agonist pharmacological group on the basis of mechanism of action. It is also classified under Diagnostic Aids .

Molecular Weight: 1182.3 · Solubility in Water: soluble 1gm in 25ml water DIN · Solubility in Alcohol: Sparing soluble · Non-proprietary name: Gonadorelin (HCl).

Molecular structure of Gonadorelin (HCl)

Pharmacokinetics

Elimination: plasma half-life is 4 min, renal excretion is major.

Indications

Gonadorelin (HCl) is primarily indicated in conditions like Amenorrhoea, Infertility, Precocious puberty, Prostate cancer.

Contraindications

Gonadorelin (HCl) is contraindicated in conditions like Genital bleeding, Ovarian failure.

Dosage

Gonadorelin (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 ug	15 ug	—		Amenorrhea & infertility.
100 ug	100 ug	—	IV	As Required For the evaluation of ganaslropic funtion of anterior pituitary.
100 ug	100 ug	—	SC	As Required
Paediatric Dosage (20kg)
0 – 0	—	—		Not licensed for used in children under 1 year.
Neonatal Dosage (3kg)
12.5 ug/kg	12.5 ug/kg	—	Intravenous
12.5 ug/kg	12.5 ug/kg	—	Subcutaneous

Drug Interactions

Unknown5 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Gonadorelin (HCl) produces potentially life-threatening effects which include Anaphylactic reactions. Careful monitoring is needed with proper medical management.

Gonadorelin (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Flushing, Headache, Hypersensitivity reactions, Increase menstrual bleeding, Irritation at injection site, Light headedness, Local swelling, Nausea, Pruritus , Septicemia, Skin rash, Thrombophlebitis .

Warnings / Precautions

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Gonadorelin (HCl) is administered to a nursing woman. Safety and effectiveness in pediatric patients have not been established.pipuitary adenoma, pregnancy, lactation DIN. Thyroid & adrenal should be evaluated.

Available Brands

None recorded.

Storage Conditions

Gonadorelin (HCl) should be stored Inj.

Drug Classification

1.18.6 — Ovulation stimulants