Glymidine
Also known as: Glycodiazine
Glymidine is oral hypoglycemic agent. Glymidine is used to reduce the blood sugar level in the treatment of type 2 diabetes mellitus.
Primary Characteristics
Glymidine is also known as Glycodiazine.
It is of Synthetic origin and belongs to Pyrimidine.
It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea pharmacological group.
Molecular Weight: 331.3 · pKa: 5.7 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1 in 110 · Non-proprietary name: Glymidine.
Pharmacokinetics
Absorption: Glymidine has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 5% (±5%).
Distribution: Glymidine has a plasma protein binding is 80%.
Elimination: it is metabolised via extensive by Liver, plasma half-life is 2-10 hr, renal excretion is 95%.
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Indications
Glymidine is primarily indicated in conditions like Maturity onset diabetes, Non-insulin dependent diabetes mellitus.
Contraindications
Glymidine is contraindicated in conditions like Renal failure, Iddm, Ketosis, Hepatic failure.
Dosage
Glymidine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 – 500 mg | — | — | PO | As Required. Befere breakfast And if required an additional dose may be taken before meal. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Glymidine in overdosage may give rise to further complications which include Hypoglycemia.
Glymidine produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia, Hypoglycemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Glymidine are Hypoglycemia.
Glymidine is known to cause more or less tolerable side effects which are usually transient. These include Arthralgia, Backache , Changes in LFT , dizziness, Dryness of mouth, Epigastric discomfort, Fatigue, GI upset, Pancytopenia , Pruritus , Skin rashes, Weakness.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.7.2 — Oral hypoglycemics