Gliquidone
Gliquidone is a oral hypoglycemic agent. Gliquidone is used in the treatment of non-insulin dependent diabetes. Gliquidone is used in conjunction with proper diet and exercise to decrease blood sugar levels. Gliquidone is used when there is a great danger of hypoglycemia (in the elderly).
Primary Characteristics
It is of Synthetic origin and belongs to Sulphonylurea.
It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea pharmacological group.
Molecular Weight: 527.6 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: > 1 in 1000 · Non-proprietary name: Gliquidone.
Pharmacokinetics
Absorption: Gliquidone has an oral bioavailability is 95%.
Distribution: Gliquidone has a volume of distribution is 11 litre. plasma protein binding is > 99%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 1.4hr(alpha phase) -16.5hr(beta phase), renal excretion is 5%.
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Indications
Gliquidone is primarily indicated in conditions like Maturity onset diabetes, NIDDM.
Contraindications
Gliquidone is contraindicated in conditions like Renal failure, Iddm, Liver diseases, Diabetic coma.
Dosage
Gliquidone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 – 0 mg | — | — | PO | |
| 52.5 mg | 52.5 mg | — | PO | Initial dose before breakfast (2 or 3 unequally divided in morning in breakfast) doses the largest dose taken. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Gliquidone in overdosage may give rise to further complications which include Allergic reactions , Skin reactions , Headache , Malaise , GI intolerance, Altered consciousness, Hypoglycemia.
The signs and symptoms that are produced after acute overdosage of Gliquidone are Seizures, Drowsiness, Drowsiness, Confusion , Hypoglycemia, Sweating , Sweating, Hunger , Trembling .
Gliquidone is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, GI symptoms, Nausea, Vomiting .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.7.2 — Oral hypoglycemics