Gliclazide
Also known as: Glicazida
Gliclazide is a sulfonyl urea compound. Gliclazide is oral hypoglycemic agent and effective in the treatment of non-insulin dependent diabetes. Gliclazide is used in conjunction with proper diet and exercise to decrease blood sugar levels. It also reduces the cardiovascular complications of diabetic patient.
Primary Characteristics
Gliclazide is also known as Glicazida.
It is of Synthetic origin and belongs to Sulphonyl Urea.
It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea pharmacological group.
Molecular Weight: 323.4 · pKa: 5.8 · Solubility in Water: soluble · Non-proprietary name: Gliclazide.
Pharmacokinetics
Absorption: Gliclazide has an oral bioavailability is 82.5% (±2.5%).
Distribution: Gliclazide has a volume of distribution is 25 litre. plasma protein binding is 91%.
Elimination: it is metabolised via extensive, plasma half-life is 10 hr, renal excretion is 80%.
Advertisement
Indications
Gliclazide is primarily indicated in conditions like Diabetes mellitus type-ii.
Contraindications
Dosage
Gliclazide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 60 mg | 60 mg | Every 24h | PO | Max dose 320 mg. doses > 160 mg given in 2 divided doses. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Gliclazide in overdosage may give rise to further complications which include GI symptoms, Dermatological reactions , Hypoglycemia.
Gliclazide produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia, Brain damage, Hypoglycemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Gliclazide are Hypoglycemia, Cerebral edema.
Gliclazide is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, GI upset, Headache, Nausea, Skin rashes.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.18.7.2 — Oral hypoglycemics