Glibornuride
Glibornuride is oral hypoglycemic agent. Glibornuride is used to reduce the blood sugar level in the treatment of type 2 diabetes mellitus.
Primary Characteristics
It is of Synthetic origin and belongs to Sulphonylurea.
It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea pharmacological group.
Molecular Weight: 366.5 · pKa: 4.7 · Solubility in Water: Insoluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Glibornuride.
Pharmacokinetics
Absorption: Glibornuride has an oral bioavailability is 98%.
Distribution: Glibornuride has a volume of distribution is 18.6 litre. plasma protein binding is 94.5%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 8.2 hr, renal excretion is 60-72%.
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Indications
Glibornuride is primarily indicated in conditions like Type II diabetes mellitus.
Contraindications
Glibornuride is contraindicated in conditions like Renal diseases, Hepatic disease, Iddm, Diabetic coma.
Dosage
Glibornuride's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 12.5 – 15 mg | — | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Glibornuride produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia, Hypoglycemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Glibornuride are Coma, Drowsiness, Drowsiness, Confusion , Hypoglycemia, Sweating , Restlessness , Sweating, Hunger , Trembling .
Glibornuride is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Nausea, SweatingX.
Warnings / Precautions
Interference in Pathology
Glibornuride may interfere in the diagnosis of Altered liver euzyme value, No effects on blood levels.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.7.2 — Oral hypoglycemics