Glibenclamide

Also known as: Glyburide

Drug #337

Glibenclamide is a oral hypoglycemic agent. Glibenclamide is used in the treatment of non-insulin dependent diabetes. Glibenclamide is used in conjunction with proper diet and exercise to decrease blood sugar levels.

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Primary Characteristics

Glibenclamide is also known as Glyburide.

It is of Synthetic origin and belongs to Sulphonylurea.

It belongs to Cyclo-oxygenase inhibitor , Potassium Channel (ATP sensitive) antagonist , Cyclo-oxygenase inhibitor , Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea , Antidiabetic Agent, Sulfonylurea pharmacological group. It is also classified under Drugs Afecting Glucose Metabolism , Drugs Afecting Glucose Metabolism .

Molecular Weight: 494 · pK_a: 5.3 · Solubility in Water: Insoluble · Solubility in Alcohol: Slightly Soluble · Non-proprietary name: Glibenclamide.

Pharmacokinetics

Absorption: Glibenclamide has an oral bioavailability is 95% (±5%).

Distribution: Glibenclamide has a volume of distribution is 0.15 l/kg. plasma protein binding is 99%.

Elimination: it is metabolised via complete by liver, plasma half-life is 5.05 hr, renal excretion is 50%.

Indications

Glibenclamide is primarily indicated in conditions like Non-insulin dependent diabetes mellitus, Softening and dilatation of cervix before mechanical cervical dilatation.

Contraindications

Glibenclamide is contraindicated in conditions like Renal failure, Liver diseases, Diabetic coma, Impaired renal function, Insulin dependent diabetes mellitus.

Dosage

Glibenclamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.5 – 5 mg	—	Every 24h	PO	Dose may be adjusted by 2.5 mg or 5 mg daily upto 15mg & 20mg
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown4 interactions

5 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Glibenclamide in overdosage may give rise to further complications which include Thrombocytopenia , Cholestatic jaundice , Aplastic anemia , Hemolytic anemia , Cholestatic jaundice , Aplastic anemia , Hemolytic anemia , Leucopenia, Agranulocytosis , Pancytopenia , Hemolytic anemia, Aplastic anemia.

Glibenclamide produces potentially life-threatening effects which include Hypersensitivity reactions, Hypoglycemia , Hypoglycemia, Renal failure, Pneumonia , Hypoglycemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Glibenclamide are Coma, Hypoglycemia, Cerebral damage.

Glibenclamide is known to cause more or less tolerable side effects which are usually transient. These include Allergic skin reactions, GI upset, Heart burn, Hepatitis, Hypoglycemia, Nausea.

Warnings / Precautions

During treatment with glibenclamide, compliance to diet and regular tablet intake are of utmost importance to preserve the efficacy of treatment and to avoid unwanted changes in the blood sugar levels. Hypoglycemic reactions may provoked by overdosage of glibenclamide, interacting drugs , dietary errors (omitting meals), the signs of it being headache, irritability, restlessness, profuse sweating, insomnia, tremor, impairment of performence and alertness, such hupoglycemic episodes are nearly always promptly relieved by the intake of sugar.

Available Brands

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Single Ingredient

Tabs

2.5 mg 5 mg 50 mg

Multi-Ingredient Combinations

Tabs

1.25 mg 2.5 mg 5 mg

Storage Conditions

Glibenclamide should be stored . Tab.

Drug Classification

1.18.7.2 — Oral hypoglycemics

Manufacturers

Manufacturers of Glibenclamide in Pakistan: