Gemeprost

Drug #334

Gemeprost is a synthetic prostaglandin. Gemeprost is used to to prepare the uterus for surgical termination of pregnancy.

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Primary Characteristics

It is of Synthetic origin and belongs to Oxocyclopentylheptenoate.

It belongs to PGF-II alpha-agonist pharmacological group on the basis of mechanism of action and also classified in Abortifacients pharmacological group.

Molecular Weight: 394 · Solubility in Water: Insoluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Gemeprost.

Pharmacokinetics

Elimination: it is metabolised via rapid, plasma half-life is 10-15 mins, renal excretion is 33%.

Indications

Gemeprost is primarily indicated in conditions like Abortion, Second trimester abortion, Second trimester intra-uterine death, Transcervical operative procedures in first trimester.

Contraindications

Gemeprost is contraindicated in conditions like Asthma, Bronchospasm.

Dosage

Gemeprost's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 mg	1 mg	Every 8h
0.014 mg/kg	0.014 mg/kg	—	Intra Vaginal	As Required, prior to surgery
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Gemeprost produces potentially life-threatening effects which include Myocardial infarction, Severe hypertension, Coronary artery spasm. Careful monitoring is needed with proper medical management.

Gemeprost is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Diarrhea, Dyspepsia , Eczema, Fatigue, GI symptoms, Mild uterine pain, Rashes , Vaginal bleeding.

Warnings / Precautions

Gemeprost should be used with caution in patients with obstructive air way disease, cardiovascular disease, raised intraocular pressure. Avoid use in women with history of uterine surgery. Cervittis or vaginitis. Pulse and Blood pressure should be monitored.

Interference in Pathology

Gemeprost may interfere in the diagnosis of No significant effect were recorded on Alkaline Phosphate or on hemosfatic system..

Available Brands

None recorded.

Storage Conditions

Gemeprost should be stored Pessary.

Drug Classification

1.22.1.1 — Oxytocics