Gemfibrozil
Gemfibrozil is antihyperlipidimic agent and reduces high levels of blood cholesterol. Gemfibrozil is the congener of the first generation fibric acid derivative clofibrate. It differs from clofibrate in its aliphatic chain and has two methyl groups rather than a chlorine atom on the phenoxy group.
Primary Characteristics
It is of Synthetic origin and belongs to Fibrates.
It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.
Molecular Weight: 250.4 · pKa: 4.7 · Solubility in Water: InSoluble · Solubility in Alcohol: Slouble · Non-proprietary name: Gemfibrozil.
Pharmacokinetics
Absorption: Gemfibrozil has an oral bioavailability is 100%.
Distribution: Gemfibrozil has a volume of distribution is 0.14l/kg. plasma protein binding is 95%.
Elimination: plasma half-life is 1.5 hr, renal excretion is 70%.
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Indications
Gemfibrozil is primarily indicated in conditions like Coronary heart disease, Hyperlipidaemias of type IIa, IIb, III and IV in patients who have not responded adequately to diet., Hyperlipoproteinaemia.
Contraindications
Gemfibrozil is contraindicated in conditions like Gall stones, Hepatic disease.
Dosage
Gemfibrozil's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.9 – 1.2 g | — | — | PO | In two divided doses given 30 min before the morning and evening meals |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Gemfibrozil in overdosage may give rise to further complications which include Myositic syndrome .
Gemfibrozil produces potentially life-threatening effects which include Arrhythmias, Hypokalemia, Hypokalemia. Careful monitoring is needed with proper medical management.
Gemfibrozil is known to cause more or less tolerable side effects which are usually transient. These include Dermatitis, Gall stones, GI symptoms, Headache, Impotence, Nausea.
Warnings / Precautions
Interference in Pathology
Gemfibrozil may interfere in the diagnosis of High level of Aaminotransfraces, Decrease in WBC or hemotocnt.
Available Brands
Storage Conditions
Drug Classification
- 1.12.6 — Lipid-regulating drugs /Anti-atheromas