Gelatin Plasma Substitutes

Drug #333

Gelatin Plasma Substitutesuse in plasma volume replacement and as fluid replacement in plasma exchange procedures. They are osmotically active colloid solutions with a colloid osmotic pressure simmilar to that of plasma which transiently retain fluid in the intravascular space until the gelation is removed by distribution and renal excretion.

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Primary Characteristics

It is of Natural origin and belongs to Polypeptide1.

It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action.

Molecular Weight: 35000 · Non-proprietary name: Gelatin Plasma Substitutes · pH: 7.2.

Molecular structure of Gelatin Plasma Substitutes

Pharmacokinetics

Distribution: Gelatin Plasma Substitutes has a volume of distribution is 120 ml/kg.

Elimination: it is metabolised via 3% by lungs, plasma half-life is / 4 hr, renal excretion is >60%.

Indications

Gelatin Plasma Substitutes is primarily indicated in conditions like Haemorrhage, Hypovolaemia, Low blood volume, Pruritus.

Contraindications

None recorded.

Dosage

Gelatin Plasma Substitutes's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
750 ml	750 ml	—	IV Inf	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Gelatin Plasma Substitutes in overdosage may give rise to further complications which include Allergic reactions , Volume overload .

Gelatin Plasma Substitutes produces potentially life-threatening effects which include Anaphylactoid reactions . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Gelatin Plasma Substitutes are Volume overload, Reversible development of vacuolar change in renal eputhelial cells.

Gelatin Plasma Substitutes is known to cause more or less tolerable side effects which are usually transient. These include Transient increase in bleeding time.

Warnings / Precautions

These solutions should not be used if the seal is broken or the solution is cloudy. Use with caution in patients with cardiac disease, severe liver disease or renal impairement urine output shall be monitored.

Interference in Pathology

Gelatin Plasma Substitutes may interfere in the diagnosis of Serum Tests for Lipase and Creatine , Thymol Turbidity Test .

Available Brands

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Multi-Ingredient Combinations

Inf

40 g/L

Storage Conditions

Gelatin Plasma Substitutes should be stored . IV inf.

Drug Classification

1.11.1 — Plasma substitutes

Manufacturers

Manufacturers of Gelatin Plasma Substitutes in Pakistan:

Usmanco