Fructose

Also known as: Fruit Sugar, Levulose

Drug #329

Fructose used as a carbohydrate nutrient. itused in patient requiring fluid replacement and caloric feeding.

Primary Characteristics

Fructose is also known as Fruit Sugar, Levulose.

It is of Natural origin and belongs to Carbohydrate.

It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action and also classified in Parenteral Nutrition pharmacological group.

Molecular Weight: 180.2 · pK_a: 12 · Solubility in Water: 1 in 0.3 · Solubility in Alcohol: 1 in 15 · Non-proprietary name: Fructose · pH: 5.9 · Isotonic value: 5.05.

Pharmacokinetics

Absorption: Fructose has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 50%.

Elimination: it is metabolised via Hepatic, plasma half-life is ~18 min, renal excretion is 1.5%.

Indications

Fructose is primarily indicated in conditions like Nausea and vomiting, Parenteral nutrition.

Contraindications

Fructose is contraindicated in conditions like Liver diseases, Erratic fructose metabolism disease, Lactic acidosis, Methanol poisoning.

Dosage

Fructose's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 %	5 %	—	IV Inf	500-1000 ml as required.
750 mg/ kg/hr	750 mg/ kg/hr	—	IV Inf	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fructose in overdosage may give rise to further complications which include Hyperuricemia, Lactic acidosis.

Fructose produces potentially life-threatening effects which include Blood lactate increase. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Fructose are Diuresis, Hyperosmolarity .

Fructose is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Facial flushing, Flatulence, Hyperuricemia , Sweating .

Warnings / Precautions

Fructose should be used with caution in patients with known subclinical diabetes mellitus. It should be given with extreme caution to patients with impaired kidney function or severe liver damage. Should not be given to hereditary fructose intolerance.

Interference in Pathology

Fructose may interfere in the diagnosis of Serum test for Creatinine and Glucose , Urine test for Creatine, Corticosteroids and metabolites, oestrogens and sugar .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inf

5 %w/v 5 g

Storage Conditions

Fructose should be stored IV Inj.

Drug Classification

1.26.2.2 — Caloric solutions

Manufacturers

Manufacturers of Fructose in Pakistan:

Frontier Medipak