Flutamide
Flutamide is anticancer drug, also called as antineoplastic agent. Flutamide is used in the treatment of prostate cancer. Flutamide is used in combination with other anti-cancer drugs to obtain most excellent therapeutic effects and to reduce the side effects or toxicities.
Primary Characteristics
It is of Synthetic origin and belongs to Toluidide.
It belongs to Androgen antagonist pharmacological group on the basis of mechanism of action and also classified in Prostatic Hyperplasia pharmacological group.
Molecular Weight: 276.2 · Solubility in Water: Insoluble · Solubility in Alcohol: high · Non-proprietary name: Flutamide.
Pharmacokinetics
Absorption: Flutamide has an oral bioavailability is 94% (±4%), pre-systemic (first-pass) metabolism accounts for 100%.
Distribution: Flutamide has a plasma protein binding is 90%.
Elimination: it is metabolised via rapid, plasma half-life is 7.8 hr, renal excretion is major.
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Indications
Flutamide is primarily indicated in conditions like Advanced prostate cancer, Benign prostatic hyperplasia, Oncology, Prostatic cancer.
Contraindications
None recorded.
Dosage
Flutamide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 250 mg | 250 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Flutamide in overdosage may give rise to further complications which include Gynacomastia , Hepatic necrosis , Cholestatic jaundice , Breast tenderness , Hepatic damage , Hepatic encephalopathy .
Flutamide produces potentially life-threatening effects which include Hepatic injury. Careful monitoring is needed with proper medical management.
Flutamide is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Nausea.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.29 — Drugs used in renal, bladder, and prostatic disorders