Fluvoxamine (Maleate)
Fluvoxamine (Maleate) is antidepressant drug and belongs to SSRIs (selective serotinin reuptake inhibitors) and is used in the treatment of obsessive compulsive disorders. Fluvoxamine (Maleate) is also used for depression. Fluvoxamine (Maleate) is less effective than fluoxetine in treating depression.
Primary Characteristics
It is of Synthetic origin and belongs to Valerophenone.
It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 434.4 · pKa: 8.7 · Solubility in Water: sparingly · Solubility in Alcohol: freely · Non-proprietary name: Fluvoxamine (Maleate).
Pharmacokinetics
Absorption: Fluvoxamine (Maleate) has an oral bioavailability is 92.5% (±2.5%).
Distribution: Fluvoxamine (Maleate) has a volume of distribution is 5 l/kg. plasma protein binding is 77%.
Elimination: it is metabolised via complete, plasma half-life is 15 hr, renal excretion is major.
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Indications
Fluvoxamine (Maleate) is primarily indicated in conditions like Depression, Depressive illness, Obsessive-compulsive disorders.
Contraindications
None recorded.
Dosage
Fluvoxamine (Maleate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg | 75 mg | Every 24h | PO | In the evening. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Fluvoxamine (Maleate) in overdosage may give rise to further complications which include Increased hepatic enzymes .
Fluvoxamine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Anorexia , Asthenia , Diarrhea, Hypokinesia , Nausea, SomnolenceX, Tremor, Vomiting .
Warnings / Precautions
Interference in Pathology
Fluvoxamine (Maleate) may interfere in the diagnosis of Urinanalysis .
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression